ARPP19 - cAMP regulated phosphoprotein 19 Gene

Homo sapiens

Also known as ENSAL; ARPP16; ARPP-16; ARPP-19

Gene ID: 10776 | Gene type: protein coding

About ARPP19

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:52,547,045-52,569,446 (from NCBI)

This gene has 13 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 79.8), thyroid (RPKM 29.3) and 24 other tissues.

Summary

The 19-kD cAMP-regulated phosphoprotein plays a role in regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed 21164014]).[supplied by OMIM, Feb 2011]

ARPP19 Products(5)

mRNA	Protein	Name
NM_001306191.2	NP_001293120.1	cAMP-regulated phosphoprotein 19 isoform 1
NM_001306195.1	NP_001293124.1	cAMP-regulated phosphoprotein 19 isoform 2
NM_001306196.2	NP_001293125.1	cAMP-regulated phosphoprotein 19 isoform 1
NM_001330309.2	NP_001317238.1	cAMP-regulated phosphoprotein 19 isoform 3
NM_006628.6	NP_006619.1	cAMP-regulated phosphoprotein 19 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	9653196	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein phosphatase 2A binding	EXP EXP: Inferred from Experiment	38123684	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	38123684	GOA
enables protein phosphatase 2A binding	IMP IMP: Inferred from mutant phenotype	38123684	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	38123684	GOA
enables protein phosphatase inhibitor activity	IMP IMP: Inferred from mutant phenotype	38123684	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9653196	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21164014	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21164014	GOA
involved in positive regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	9653196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPP19 Protein Structure

Endosulfine

0
100
112 a.a.

Protein Preferred Names

Protein Names

cAMP-regulated phosphoprotein 19

cAMP-regulated phosphoprotein 19kDa

ARPP19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARPP19	P56211	SPDYC	Homo sapiens	Q5MJ68	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01025	ARPP19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARPP19	VGNC	VGNC:38133
Felis catus	ARPP19	VGNC	VGNC:104359
Bos taurus	ARPP19	VGNC	VGNC:26167
Mus musculus	ARPP19	MGD	MGI:1891691
Rattus norvegicus	ARPP19	RGD	RGD:71054

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