2. Gene
  3. HSPH1 - heat shock protein family H (Hsp110) member 1 Gene

HSPH1 - heat shock protein family H (Hsp110) member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HSP105; HSP105A; HSP105B; NY-CO-25

Gene ID: 10808 | Gene type: protein coding

About HSPH1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:31,134,973-31,162,388 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues and 13 paralogues. Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

HSPH1 Products(12)

mRNA Protein Name
XM_017020364.3 XP_016875853.1 heat shock protein 105 kDa isoform X7
XM_017020363.3 XP_016875852.1 heat shock protein 105 kDa isoform X4
NM_001286503.2 NP_001273432.1 heat shock protein 105 kDa isoform 2
XM_011534888.3 XP_011533190.1 heat shock protein 105 kDa isoform X5
XM_011534887.4 XP_011533189.1 heat shock protein 105 kDa isoform X1
NM_001286505.1 NP_001273434.1 heat shock protein 105 kDa isoform 4
XM_005266236.3 XP_005266293.1 heat shock protein 105 kDa isoform X2
XM_047430058.1 XP_047286014.1 heat shock protein 105 kDa isoform X6
NM_006644.4 NP_006635.2 heat shock protein 105 kDa isoform 1
XM_017020362.3 XP_016875851.1 heat shock protein 105 kDa isoform X3
NM_001349704.2 NP_001336633.1 heat shock protein 105 kDa isoform 5
NM_001286504.1 NP_001273433.1 heat shock protein 105 kDa isoform 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables adenyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
24318877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17024176 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9931472 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPH1 Protein Structure

HSP70

HSP70: Hsp70 protein (3 - 705)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
Protein Preferred Names Protein Names

heat shock protein 105 kDa

antigen NY-CO-25

heat shock 105kDa/110kDa protein 1

HSPH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HSPH1 Q92598 q96be0_human Homo sapiens Q96BE0
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

HSPH1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82868 Hsp110 Antibody (YA2613) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Craniotubular Dysplasia, Ikegawa Type

CTDI

Craniotubular Dysplasia Ikegawa Type

Doid:0112340
Photokeratitis
Craniodiaphyseal Dysplasia

Schaefer Stein Oshman Syndrome

CDD

Craniodiaphyseal Dysplasia, Dominant

Dominantly Inherited Craniodiaphyseal Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06450 HSPH1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06451 Hsph1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06452 Hsph1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HSPH1 VGNC VGNC:106265
Felis catus HSPH1 VGNC VGNC:102230
Mus musculus HSPH1 MGD MGI:105053
Bos taurus HSPH1 VGNC VGNC:53817
Canis familiaris HSPH1 VGNC VGNC:59083
Rattus norvegicus HSPH1 RGD RGD:1311609