Baiap2 - brain-specific angiogenesis inhibitor 1-associated protein 2 Gene

Mus musculus

Also known as IRSp53

Gene ID: 108100 | Gene type: protein coding

About Baiap2

Summary

Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and scaffold protein binding activity. Involved in several processes, including actin filament organization; modification of synaptic structure, modulating synaptic transmission; and regulation of cell shape. Acts upstream of or within dendrite development and regulation of synaptic plasticity. Located in Schaffer collateral - CA1 synapse and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Baiap2 Products(3)

mRNA	Protein	Name
NM_001037754.3	NP_001032843.1	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform c
NM_001037755.3	NP_001032844.2	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform a
NM_130862.4	NP_570932.2	brain-specific angiogenesis inhibitor 1-associated protein 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10814512	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin crosslink formation	IMP IMP: Inferred from mutant phenotype	17115031	MGI
acts upstream of or within actin filament bundle assembly	IGI IGI: Inferred from genetic interaction	19208628	MGI
involved in actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	17115031	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	19208628	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	19193906	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	19193906	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	17115031	MGI
acts upstream of or within regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	19208628	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19193906	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19193906	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

brain-specific angiogenesis inhibitor 1-associated protein 2

BAI-associated protein 2	BAI1-associated protein 2
insulin receptor substrate p53	insulin receptor substrate protein of 53 kDa
insulin receptor tyrosine kinase 53 kDa substrate

Baiap2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Baiap2	Q8BKX1	Diaph1	Mus musculus	O08808	Far-WB	10814512
Intra	Baiap2	Q8BKX1	Diaph1	Mus musculus	O08808	Y2H	10814512
Intra	Baiap2	Q8BKX1	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	19455133
Intra	Baiap2	Q8BKX1	Iqsec2	Mus musculus	A4GZ26	Pull Down	19083995
Intra	Baiap2	Q8BKX1	Iqsec2	Mus musculus	A4GZ26	Y2H	19083995
Intra	Baiap2	Q8BKX1	Iqsec2	Mus musculus	A4GZ26	Anti Bait CoIP	19083995

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01353	BAIAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01354	BAIAP2L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01355	BAIAP2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Baiap2	NCBI	NCBI:10458

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