2. Gene
  3. USP19 - ubiquitin specific peptidase 19 Gene

USP19 - ubiquitin specific peptidase 19 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZMYND9

Gene ID: 10869 | Gene type: protein coding

About USP19

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,108,050-49,120,823 (from NCBI)

This gene has 14 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein Ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

USP19 Products(40)

mRNA Protein Name
NM_001199160.2 NP_001186089.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 1
NM_001199161.2 NP_001186090.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 2
NM_001199162.2 NP_001186091.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 3
NM_001351098.2 NP_001338027.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 5
NM_001351099.2 NP_001338028.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 6
NM_001351100.2 NP_001338029.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 7
NM_001351101.2 NP_001338030.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 8
NM_001351102.2 NP_001338031.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 9
NM_001351103.2 NP_001338032.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 10
NM_001351104.2 NP_001338033.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 11
NM_001351105.2 NP_001338034.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 12
NM_001351106.2 NP_001338035.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 13
NM_001351107.2 NP_001338036.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 14
NM_001351108.2 NP_001338037.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 15
NM_001389594.1 NP_001376523.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 16
NM_001389595.1 NP_001376524.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 17
NM_001389596.1 NP_001376525.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 18
NM_001389597.1 NP_001376526.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 19
NM_001389598.1 NP_001376527.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 20
NM_001389599.1 NP_001376528.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 21
NM_001389600.1 NP_001376529.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 22
NM_001389601.1 NP_001376530.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 23
NM_001389602.1 NP_001376531.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 24
NM_001389603.1 NP_001376532.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 25
NM_001389604.1 NP_001376533.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 26
NM_001389605.1 NP_001376534.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 27
NM_001389606.1 NP_001376535.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 28
NM_001389607.1 NP_001376536.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 29
NM_001389608.1 NP_001376537.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 30
NM_001400288.1 NP_001387217.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 16
NM_001400290.1 NP_001387219.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 36
NM_001400292.1 NP_001387221.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 2
NM_001400293.1 NP_001387222.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 20
NM_001400294.1 NP_001387223.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 31
NM_001400295.1 NP_001387224.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 32
NM_001400296.1 NP_001387225.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 33
NM_001400297.1 NP_001387226.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 14
NM_001400298.1 NP_001387227.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 34
NM_001400299.1 NP_001387228.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 35
NM_006677.3 NP_006668.1 ubiquitin carboxyl-terminal hydrolase 19 isoform 4

USP19 Protein Structure

CS

CS: CS domain (119 - 191)

CS

CS: CS domain (287 - 374)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (497 - 1211)

zf-MYND

zf-MYND: MYND finger (791 - 833)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1318 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 19

deubiquitinating enzyme 19

Related Diseases

Diseases Alias
Pitt-Hopkins-Like Syndrome 2

PTHSL2

Mesh

D006985

Mesh

D008607
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15529 USP19 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus USP19 MGD MGI:1918722
Felis catus USP19 VGNC VGNC:66871
Canis familiaris USP19 VGNC VGNC:48181
Bos taurus USP19 VGNC VGNC:36714
Macaca mulatta USP19 VGNC VGNC:78739
Rattus norvegicus USP19 RGD RGD:1303276