USP19 - ubiquitin specific peptidase 19 Gene

Homo sapiens

Also known as ZMYND9

Gene ID: 10869 | Gene type: protein coding

About USP19

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,108,050-49,120,823 (from NCBI)

This gene has 14 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 12.9), thyroid (RPKM 11.3) and 25 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein Ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

USP19 Products(40)

mRNA	Protein	Name
NM_001199160.2	NP_001186089.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 1
NM_001199161.2	NP_001186090.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 2
NM_001199162.2	NP_001186091.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 3
NM_001351098.2	NP_001338027.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 5
NM_001351099.2	NP_001338028.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 6
NM_001351100.2	NP_001338029.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 7
NM_001351101.2	NP_001338030.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 8
NM_001351102.2	NP_001338031.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 9
NM_001351103.2	NP_001338032.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 10
NM_001351104.2	NP_001338033.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 11
NM_001351105.2	NP_001338034.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 12
NM_001351106.2	NP_001338035.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 13
NM_001351107.2	NP_001338036.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 14
NM_001351108.2	NP_001338037.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 15
NM_001389594.1	NP_001376523.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 16
NM_001389595.1	NP_001376524.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 17
NM_001389596.1	NP_001376525.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 18
NM_001389597.1	NP_001376526.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 19
NM_001389598.1	NP_001376527.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 20
NM_001389599.1	NP_001376528.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 21
NM_001389600.1	NP_001376529.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 22
NM_001389601.1	NP_001376530.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 23
NM_001389602.1	NP_001376531.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 24
NM_001389603.1	NP_001376532.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 25
NM_001389604.1	NP_001376533.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 26
NM_001389605.1	NP_001376534.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 27
NM_001389606.1	NP_001376535.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 28
NM_001389607.1	NP_001376536.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 29
NM_001389608.1	NP_001376537.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 30
NM_001400288.1	NP_001387217.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 16
NM_001400290.1	NP_001387219.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 36
NM_001400292.1	NP_001387221.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 2
NM_001400293.1	NP_001387222.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 20
NM_001400294.1	NP_001387223.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 31
NM_001400295.1	NP_001387224.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 32
NM_001400296.1	NP_001387225.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 33
NM_001400297.1	NP_001387226.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 14
NM_001400298.1	NP_001387227.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 34
NM_001400299.1	NP_001387228.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 35
NM_006677.3	NP_006668.1	ubiquitin carboxyl-terminal hydrolase 19 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	24356957	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	19465887	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	24356957	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19465887	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	19465887	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	24356957	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25088257	GOA
involved in regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	25088257	GOA
involved in regulation of cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	22128162	GOA
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	19465887	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	24356957	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	19465887	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP19 Protein Structure

UCH

zf-MYND

0
300
600
900
1200
1318 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 19

deubiquitinating enzyme 19

USP19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP19	O94966	CFTR	Homo sapiens	P13569	Anti Tag CoIP	19465887

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pitt-Hopkins-Like Syndrome 2

PTHSL2	Mesh
D006985	Mesh
D008607

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15529	USP19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	USP19	MGD	MGI:1918722
Felis catus	USP19	VGNC	VGNC:66871
Canis familiaris	USP19	VGNC	VGNC:48181
Bos taurus	USP19	VGNC	VGNC:36714
Macaca mulatta	USP19	VGNC	VGNC:78739
Rattus norvegicus	USP19	RGD	RGD:1303276

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