2. Gene
  3. ACTL7A - actin like 7A Gene

ACTL7A - actin like 7A Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as SPGF86

Gene ID: 10881 | Gene type: protein coding

About ACTL7A

Summary

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]

ACTL7A Products(1)

mRNA Protein Name
NM_006687.4 NP_006678.1 actin-like protein 7A
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21278383 GOA
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
32923619 GOA
located in acrosomal vesicle IMP
IMP: Inferred from mutant phenotype
34727571 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
21278383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin-like protein 7A

actin-like 7-alpha

testicular secretory protein Li 3

ACTL7A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ACTL7A Q9Y615 TES Homo sapiens Q9UGI8
X-Ray Diffraction
21278383
Cross: Cross-species interaction Intra: Intraspecies interaction