SMPDL3A - sphingomyelin phosphodiesterase acid like 3A Gene

Homo sapiens

Also known as ASM3A; ASML3a; yR36GH4.1

Gene ID: 10924 | Gene type: protein coding

About SMPDL3A

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,789,258-122,809,720 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 18.5), small intestine (RPKM 18.4) and 25 other tissues.

Summary

Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in nucleoside triphosphate catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SMPDL3A Products(2)

mRNA	Protein	Name
NM_001286138.2	NP_001273067.1	acid sphingomyelinase-like phosphodiesterase 3a isoform b
NM_006714.5	NP_006705.1	acid sphingomyelinase-like phosphodiesterase 3a isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoric diester hydrolase activity	IDA IDA: Inferred from direct assay	26783088	GOA
enables phosphoric diester hydrolase activity	IMP IMP: Inferred from mutant phenotype	37890481	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12442002	GOA
NOT enables sphingomyelin phosphodiesterase activity	IDA IDA: Inferred from direct assay	26783088	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	26783088	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cGAS/STING signaling pathway	IMP IMP: Inferred from mutant phenotype	37890481	GOA
involved in nucleoside triphosphate catabolic process	IDA IDA: Inferred from direct assay	26783088	GOA
NOT involved in sphingomyelin catabolic process	IDA IDA: Inferred from direct assay	26783088	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	28104755	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25288789	GOA
is active in extracellular space	IMP IMP: Inferred from mutant phenotype	37890481	GOA
located in extracellular space	IMP IMP: Inferred from mutant phenotype	26783088	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMPDL3A Protein Structure

Metallophos

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

acid sphingomyelinase-like phosphodiesterase 3a

0610010C24Rik

Recombinant SMPDL3A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71325	SMPDL3A Protein, Human (HEK293, His)	Q92484-1 (L23-Y453)	≥95%

Related Diseases

Diseases

Alias

Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13451	SMPDL3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMPDL3A	RGD	RGD:1359277
Bos taurus	SMPDL3A	VGNC	VGNC:35033
Felis catus	SMPDL3A	VGNC	VGNC:65504
Mus musculus	SMPDL3A	MGD	MGI:1931437
Macaca mulatta	SMPDL3A	VGNC	VGNC:77731
Canis familiaris	SMPDL3A	VGNC	VGNC:46573
Others	SMPDL3A	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.