APOBEC2 - apolipoprotein B mRNA editing enzyme catalytic subunit 2 Gene

Homo sapiens

Also known as ARP1; ARCD1

Gene ID: 10930 | Gene type: protein coding

About APOBEC2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,053,202-41,064,891 (from NCBI)

This gene has 1 transcript (splice variant), 259 orthologues and 9 paralogues. Biased expression in heart (RPKM 45.3), prostate (RPKM 9.9) and 1 other tissue.

Summary

Enables cytidine deaminase activity and identical protein binding activity. Involved in DNA demethylation. Acts upstream of or within cytidine to uridine editing. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

APOBEC2 Products(1)

mRNA	Protein	Name
NM_006789.4	NP_006780.1	C->U-editing enzyme APOBEC-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytidine deaminase activity	IDA IDA: Inferred from direct assay	10403781	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17187054	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytidine to uridine editing	IDA IDA: Inferred from direct assay	10403781	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	21496894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC2 Protein Structure

APOBEC_N

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

C->U-editing enzyme APOBEC-2

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2

APOBEC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOBEC2	Q9Y235	APOBEC2	Homo sapiens	Q9Y235	GMS	17187054
Intra	APOBEC2	Q9Y235	APOBEC2	Homo sapiens	Q9Y235	X-Ray Diffraction	17187054

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cataract 6, Multiple Types

Ctpp1	Cataract 6 Multiple Types
CTRCT6	Cataract, Posterior Polar, 1
Arcc2	Cataract, Age-Related Cortical, 2
Ctpa	Ctpp
Age Related Cortical Cataract 2	Posterior Polar Cataract 1
Posterior Polar Cataract, 1	Age-Related Cortical Cataract 2
Cataract Posterior Polar 1

Immunodeficiency With Hyper-Igm, Type 2

HIGM2	Hyper-Igm Syndrome Type 2
Hyper-Igm Syndrome 2	Immunodeficiency With Hyper-Igm Type 2
Activation-Induced Cytidine Deaminase Deficiency	Aid Deficiency
Immunodeficiency With Hyper Igm Type 2	Hyper Igm Syndrome 2
Immunodeficiency With Hyper-Igm 2	Hyper-Igm Immunodeficiency Type 2
Immunodeficiency, With Hyper Igm, Type 2	Hyper-Igm Immunodeficiency Syndrome, Type 2

Intellectual Developmental Disorder, Autosomal Dominant 22

MRD22	Mental Retardation, Autosomal Dominant 22
Autosomal Dominant Non-Syndromic Intellectual Disability 22	Distal Monosomy 1q
Autosomal Dominant Intellectual Developmental Disorder 22	Autosomal Dominant Mental Retardation 22
Distal Deletion 1q	Monosomy 1qter
Telomeric Deletion 1q	Mental Retardation, Autosomal Dominant, Type 22

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00835	APOBEC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APOBEC2	VGNC	VGNC:69986
Felis catus	APOBEC2	VGNC	VGNC:67795
Rattus norvegicus	APOBEC2	RGD	RGD:1308727
Mus musculus	APOBEC2	MGD	MGI:1343178
Canis familiaris	APOBEC2	VGNC	VGNC:37996
Bos taurus	APOBEC2	VGNC	VGNC:26028

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