LMAN2 - lectin, mannose binding 2 Gene

Homo sapiens

Also known as GP36B; VIP36; C5orf8

Gene ID: 10960 | Gene type: protein coding

About LMAN2

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,331,567-177,351,668 (from NCBI)

This gene has 11 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 56.0), testis (RPKM 45.6) and 25 other tissues.

Summary

This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]

LMAN2 Products(1)

mRNA	Protein	Name
NM_006816.3	NP_006807.1	vesicular integral-membrane protein VIP36 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-mannose binding	IMP IMP: Inferred from mutant phenotype	20477988	GOA
enables carbohydrate binding	IDA IDA: Inferred from direct assay	23701871	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	20477988	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20477988	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	22016386	GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	20477988	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20477988	GOA
located in cell surface	IDA IDA: Inferred from direct assay	22016386	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	22016386	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22016386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMAN2 Protein Structure

Lectin_leg-like

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

vesicular integral-membrane protein VIP36

epididymis secretory sperm binding protein

Recombinant LMAN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71151	LMAN2 Protein, Human (HEK293, His)	Q12907 (D45-R322)	≥95%

Related Diseases

Diseases

Alias

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07704	LMAN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07705	LMAN2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LMAN2	VGNC	VGNC:63246
Canis familiaris	LMAN2	VGNC	VGNC:42708
Mus musculus	LMAN2	MGD	MGI:1914140
Rattus norvegicus	LMAN2	RGD	RGD:1308965
Macaca mulatta	LMAN2	VGNC	VGNC:74302
Bos taurus	LMAN2	VGNC	VGNC:30920
Others	LMAN2	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.