CKAP4 - cytoskeleton associated protein 4 Gene

Homo sapiens

Also known as p63; CLIMP63; CLIMP-63; ERGIC-63

Gene ID: 10970 | Gene type: protein coding

About CKAP4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,237,881-106,248,020 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 7 paralogues. Ubiquitous expression in bone marrow (RPKM 41.9), placenta (RPKM 30.9) and 25 other tissues.

Summary

Enables RNA binding activity. Located in several cellular components, including lipid droplet; nuclear speck; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

CKAP4 Products(1)

mRNA	Protein	Name
NM_006825.4	NP_006816.2	cytoskeleton-associated protein 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19401338	GOA
located in lipid droplet	IDA IDA: Inferred from direct assay	14741744	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	24454821	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoskeleton-associated protein 4

63 kDa membrane protein

Recombinant CKAP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700976	CKAP4 Protein, Human (His)	Q07065 (H128-V602)	≥95%

Related Diseases

Diseases

Alias

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Bladder Exstrophy

Exstrophy Of The Bladder

Classic Exstrophy Of The Bladder

Axenfeld-Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome Type 1	RIEG1
Rieg	Rgs
Rieger Syndrome Type 1	Rieger Syndrome, Type 1
Axenfeld-Rieger Syndrome 1	Iridogoniodysgenesis With Somatic Anomalies

Retinitis Pigmentosa 20

RP20	Retinitis Pigmentosa, Type 20

Spastic Paraplegia 36, Autosomal Dominant

SPG36	Hereditary Spastic Paraplegia 36
Autosomal Dominant Spastic Paraplegia Type 36	Autosomal Dominant Spastic Paraplegia 36

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02734	CKAP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CKAP4	VGNC	VGNC:39288
Felis catus	CKAP4	VGNC	VGNC:83533
Mus musculus	CKAP4	MGD	MGI:2444926
Bos taurus	CKAP4	VGNC	VGNC:27382
Rattus norvegicus	CKAP4	RGD	RGD:1311989
Macaca mulatta	CKAP4	VGNC	VGNC:71190
Others	CKAP4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.