2. Gene
  3. CCNI - cyclin I Gene

CCNI - cyclin I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CYI; CYC1; CCNI1

Gene ID: 10983 | Gene type: protein coding

About CCNI

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,047,155-77,075,989 (from NCBI)

This gene has 9 transcripts (splice variants), 239 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 185.4), ovary (RPKM 178.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]

CCNI Products(10)

mRNA Protein Name
NM_001348132.2 NP_001335061.1 cyclin-I isoform a
NM_001348133.2 NP_001335062.1 cyclin-I isoform a
NM_001348134.2 NP_001335063.1 cyclin-I isoform b
NM_001348135.2 NP_001335064.1 cyclin-I isoform c
NM_001348136.2 NP_001335065.1 cyclin-I isoform d
NM_001348137.2 NP_001335066.1 cyclin-I isoform e
NM_001348138.2 NP_001335067.1 cyclin-I isoform f
NM_001348139.2 NP_001335068.1 cyclin-I isoform g
NM_001348140.2 NP_001335069.1 cyclin-I isoform h
NM_006835.3 NP_006826.1 cyclin-I isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25852190 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNI Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (21 - 142)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

cyclin-I

cyclin ITI

CCNI Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CCNI Q14094 CDK5 Homo sapiens Q00535
Anti Tag CoIP
33961781
Intra CCNI Q14094 CDK6 Homo sapiens Q00534
Y2H Array
32296183
Intra CCNI Q14094 CDK6 Homo sapiens Q00534
Y2H Prey Pooling
32296183
Intra CCNI Q14094 ZMYND19 Homo sapiens Q96E35
Y2H Prey Pooling
32296183
Intra CCNI Q14094 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra CCNI Q14094 ZMYND19 Homo sapiens Q96E35
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02133 CCNI Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CCNI RGD RGD:1309209
Mus musculus CCNI MGD MGI:1341077
Canis familiaris CCNI VGNC VGNC:57402
Bos taurus CCNI VGNC VGNC:26971
Felis catus CCNI VGNC VGNC:60562
Macaca mulatta CCNI VGNC VGNC:70733