2. Gene
  3. LILRB5 - leukocyte immunoglobulin like receptor B5 Gene

LILRB5 - leukocyte immunoglobulin like receptor B5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LIR8; CD85C; LIR-8

Gene ID: 10990 | Gene type: protein coding

About LILRB5

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,249,421-54,257,609 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 297 orthologues and 25 paralogues. Broad expression in spleen (RPKM 27.4), placenta (RPKM 7.8) and 15 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB5 Products(5)

mRNA Protein Name
NM_001081442.3 NP_001074911.2 leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 1 precursor
NM_001081443.3 NP_001074912.2 leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 3 precursor
NM_001304457.3 NP_001291386.2 leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 4 precursor
NM_001412269.1 NP_001399198.1 leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 5 precursor
NM_006840.5 NP_006831.2 leukocyte immunoglobulin-like receptor subfamily B member 5 isoform 2 precursor

LILRB5 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 115)

Ig_2

Ig_2: Immunoglobulin domain (120 - 208)

Ig_2

Ig_2: Immunoglobulin domain (218 - 306)

Ig_3

Ig_3: Immunoglobulin domain (315 - 387)

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  • 622 a.a.
Protein Preferred Names Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 5

CD85 antigen-like family member C

Recombinant LILRB5 Proteins

Cat. No. Product Name Accession Purity
HY-P72517 LILRB5/CD85c/LIR-8 Protein, Human (433a.a, HEK293, His) O75023-1 (G24-H456) ≥95%
HY-P77443 LILRB5/CD85c/LIR-8 Protein, Human (Biotinylated, HEK293, His) O75023-1 (G24-H456) ≥95%
HY-P78485 LILRB5/CD85c/LIR-8 Protein, Human (HEK293, His-Avi) O75023-1 (R18-H456) ≥95%
HY-P700781 LILRB5/CD85c/LIR-8 Protein, Human (Biotinylated, HEK293, His-Avi) O75023-1 (R18-H456) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07655 LILRB5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LILRB5 RGD RGD:1566307
Mus musculus LILRB5 MGD MGI:894311
Others LILRB5 NCBI