LILRB4 - leukocyte immunoglobulin like receptor B4 Gene

Homo sapiens

Also known as B4; ILT3; LIR5; CD85K; ILT-3; LIR-5

Gene ID: 11006 | Gene type: protein coding

About LILRB4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,662,985-54,668,718 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 296 orthologues and 25 paralogues. Broad expression in appendix (RPKM 9.2), lymph node (RPKM 8.1) and 17 other tissues.

Summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB4 Products(12)

mRNA	Protein	Name
NM_001278426.4	NP_001265355.2	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1 precursor
NM_001278427.4	NP_001265356.2	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor
NM_001278428.4	NP_001265357.2	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 3 precursor
NM_001278429.4	NP_001265358.3	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4
NM_001278430.4	NP_001265359.2	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5 precursor
NM_001394933.1	NP_001381862.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 6 precursor
NM_001394934.1	NP_001381863.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 7 precursor
NM_001394935.1	NP_001381864.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 8 precursor
NM_001394936.1	NP_001381865.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 9
NM_001394937.1	NP_001381866.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 10
NM_001394938.1	NP_001381867.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 11
NM_001394939.1	NP_001381868.1	leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 12 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables apolipoprotein binding	IDA IDA: Inferred from direct assay	30333625	GOA
enables fibronectin binding	IDA IDA: Inferred from direct assay	34089617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18802077	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16493035	GOA
enables signaling receptor inhibitor activity	IDA IDA: Inferred from direct assay	9151699	GOA
enables transmembrane receptor protein tyrosine kinase inhibitor activity	IDA IDA: Inferred from direct assay	9151699	GOA
enables transmembrane receptor protein tyrosine kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	16493035	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Fc receptor mediated inhibitory signaling pathway	IDA IDA: Inferred from direct assay	16493035	GOA
involved in interleukin-10-mediated signaling pathway	IEP IEP: Inferred from expression pattern	17163451	GOA
involved in negative regulation of IP-10 production	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of T cell costimulation	IMP IMP: Inferred from mutant phenotype	17163451	GOA
involved in negative regulation of T cell cytokine production	IDA IDA: Inferred from direct assay	18420485	GOA
involved in negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17163451	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	22387553	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16493035	GOA
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of cytotoxic T cell differentiation	IMP IMP: Inferred from mutant phenotype	16493035	GOA
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	18420485	GOA
involved in negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	18420485	GOA
involved in negative regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	18420485	GOA
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19380766	GOA
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	22387553	GOA
involved in negative regulation of monocyte activation	IDA IDA: Inferred from direct assay	19833736	GOA
involved in negative regulation of monocyte activation	IMP IMP: Inferred from mutant phenotype	9151699	GOA
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	18802077	GOA
involved in negative regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	22387553	GOA
involved in negative regulation of protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	9151699	GOA
involved in negative regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	16493035	GOA
involved in negative regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	9151699	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	19833736	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	20007427	GOA
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation	IDA IDA: Inferred from direct assay	18420485	GOA
involved in positive regulation of T cell anergy	IMP IMP: Inferred from mutant phenotype	16493035	GOA
involved in positive regulation of regulatory T cell differentiation	IDA IDA: Inferred from direct assay	20935202	GOA
involved in receptor internalization	IMP IMP: Inferred from mutant phenotype	9151699	GOA
involved in tolerance induction	IDA IDA: Inferred from direct assay	18420485	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9151699	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRB4 Protein Structure

Ig_2

Ig_3

0
100
200
300
400
449 a.a.

Protein Preferred Names

Protein Names

leukocyte immunoglobulin-like receptor subfamily B member 4

CD85 antigen-like family member K

LILRB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LILRB4	Q8NHJ6	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	18802077

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRB4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72519	LILRB4/CD85k/ILT3 Protein, Human (HEK293, His)	Q8NHJ6-1 (Q22-E259)	≥95%
HY-P76440	LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His)	Q8NHJ6-1 (Q22-E259)	≥95%
HY-P76441	LILRB4/CD85k/ILT3 Protein, Human (237a.a, HEK293, Fc)	Q8NHJ6-1/NP_001265356.2 (M21-H257)	≥95%
HY-P77741	LILRB4/CD85k/ILT3 Protein, Human (Domain1&2, HEK293, His)	Q8NHJ6-1 (P27-S218)	≥95%
HY-P77743	LILRB4/CD85k/ILT3 Protein, Human (HEK293, His-Avi)	Q8NHJ6-1 (Q22-H257)	≥95%
HY-P77744	LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8NHJ6-1 (Q22-H257)	≥95%
HY-P78645	FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, His)	Q8NHJ6-1 (Q22-H257)	≥95%
HY-P78646	FITC-Labeled LILRB4/CD85k/ILT3 Protein, Human (HEK293, Fc)	Q8NHJ6-1 (Q22-R256)	≥95%
HY-P700779	LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, Domain 1, HEK293, His-Avi)	AAH26309.1 (Q22-T118)	≥95%
HY-P700780	LILRB4/CD85k/ILT3 Protein, Human (Domain 1, HEK293, His-Avi)	AAH26309.1 (Q22-T118)	≥95%
HY-P701018	LILRB4/CD85k/ILT3 Protein, Human (Biotinylated, 141a.a, HEK293, His-Avi)	AAH26309.1 (G119-E259)	≥95%
HY-P701064	LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (Biotinylated, HEK293, His-Avi)	AAH26309.1 (Q22-K123)	≥95%
HY-P701065	LILRB4/CD85k/ILT3 Domain 1+hinge Protein, Human (HEK293, His-Avi)	AAH26309.1 (Q22-K123)	≥95%

LILRB4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83660	LILRB4/CD85k Antibody(YA3395)	IHC-P, ICC/IF, FC, ELISA	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07654	LILRB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990092	Rolistobart	Inhibitor	96.42%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LILRB4	RGD	RGD:1359090
Macaca fascicularis	LILRB4	NCBI	NCBI:107128256
Mus musculus	LILRB4	NCBI
Others	LILRB4	NCBI

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