PTPN6 - protein tyrosine phosphatase non-receptor type 6 Gene

Homo sapiens

Also known as HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

Gene ID: 5777 | Gene type: protein coding

About PTPN6

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,946,577-6,961,316 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues, 35 paralogues and is associated with 61 phenotypes. Broad expression in spleen (RPKM 76.2), lymph node (RPKM 74.9) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPN6 Products(3)

mRNA	Protein	Name
NM_002831.6	NP_002822.2	tyrosine-protein phosphatase non-receptor type 6 isoform 1
NM_080548.5	NP_536858.1	tyrosine-protein phosphatase non-receptor type 6 isoform 2
NM_080549.4	NP_536859.1	tyrosine-protein phosphatase non-receptor type 6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphorylation-dependent protein binding	IPI IPI: Inferred from physical interaction	11162587	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	11986327	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7228577	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11266449	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	17562706	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	10206955	GOA
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	11266449	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CD27 signaling pathway	IDA IDA: Inferred from direct assay	38354704	GOA
involved in T cell activation	IDA IDA: Inferred from direct assay	38354704	GOA
involved in cell differentiation	IDA IDA: Inferred from direct assay	11266449	GOA
involved in negative regulation of B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	35941532	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	23896411	GOA
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	34811497	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	19749791	GOA
involved in peptidyl-tyrosine dephosphorylation	IMP IMP: Inferred from mutant phenotype	17562706	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	9285411	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19749791	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19838216	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	11266449	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11266449	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19838216	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	9065461	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10940933	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19838216	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	23896411	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	17562706	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN6 Protein Structure

SH2

Y_phosphatase

0
100
200
300
400
500
595 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 6

hematopoietic cell phosphatase

PTPN6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN6	P29350	KDR	Homo sapiens	P35968	Ub Reconstruction	28065597
Intra	PTPN6	P29350	LCK	Homo sapiens	P06239	Protein Kinase Assay	8114715
Intra	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Bait CoIP	20351292
Intra	PTPN6	P29350	NFAT5	Homo sapiens	O94916-1	Anti Tag CoIP	20351292
Intra	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	31980649
Intra	PTPN6	P29350	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	33961781
Intra	PTPN6	P29350	LILRB4	Homo sapiens	Q8NHJ6	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB1	Homo sapiens	Q8NHL6	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB2	Homo sapiens	Q8N423	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	LILRB3	Homo sapiens	O75022	Anti Bait CoIP	18802077
Intra	PTPN6	P29350	THEMIS	Homo sapiens	Q8N1K5	Anti Bait CoIP	25535246
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10206955
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	CoIP	10556798
Intra	PTPN6	P29350	CD33	Homo sapiens	P20138	Enzymatic Study	10556798
Intra	PTPN6	P29350	IGF1R	Homo sapiens	P08069	Ub Reconstruction	28065597
Intra	PTPN6	P29350	CD37	Homo sapiens	P11049	Anti Bait CoIP	22624718
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Affinity Chrom	7228577
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7228577
Intra	PTPN6	P29350	EPOR	Homo sapiens	P19235	Pull Down	7528577
Cross	PTPN6	P29350	tir	Escherichia coli O157:H7	Q7DB77	Anti Tag CoIP	23001144
Intra	PTPN6	P29350	PECAM1	Homo sapiens	P16284	Pull Down	9774457
Intra	PTPN6	P29350	PECAM1	Homo sapiens	P16284	SPR	9774457
Intra	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	SELDI Chip	8577729
Intra	PTPN6	P29350	FCGR2B	Homo sapiens	P31994	Affinity Chrom	9148918
Intra	PTPN6	P29350	ROS1	Homo sapiens	P08922	Pull Down	11266449
Intra	PTPN6	P29350	ROS1	Homo sapiens	P08922	CoIP	11266449
Intra	PTPN6	P29350	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	18086677
Intra	PTPN6	P29350	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	18086677
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8691154
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Pull Down	8648092
Intra	PTPN6	P29350	KIR2DL3	Homo sapiens	P43628	Affinity Chrom	9148918
Intra	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	CoIP	8691146
Intra	PTPN6	P29350	KIR2DL1	Homo sapiens	P43626	Pull Down	8691146
Intra	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	SPR	10660620
Intra	PTPN6	P29350	PILRA	Homo sapiens	Q9UKJ1	Y2H	10660620
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Pull Down	10764762
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	Y2H	10660620
Intra	PTPN6	P29350	LAIR1	Homo sapiens	Q6GTX8	CoIP	10764762
Cross	PTPN6	P29350	tir	Escherichia coli O127:H6	B7UM99	Pull Down	23001144
Cross	PTPN6	P29350	Ppp1r9b	Rattus norvegicus	O35274	Anti Tag CoIP	25785436

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPN6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71141	SHP-1 Protein, Human (His)	AAH02523.1 (K243-I541)	≥95%

Related Diseases

Diseases

Alias

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Erythrocytosis, Familial, 1

ECYT1	Pfcp
Primary Familial And Congenital Polycythemia	Familial Erythrocytosis 1
Familial Erythrocytosis	Polycythemia, Primary Familial And Congenital
Autosomal Dominant Benign Erythrocytosis	Familial Erythrocytosis Type 1
Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation	Congenital Polycythemia Due To Erythropoietin Receptor Mutation
Primary Congenital Erythrocytosis	Primary Familial Polycythemia
Erythrocytosis, Autosomal Dominant Benign	Erythrocytosis, Somatic
Autosomal Dominant Familial Erythrocytosis-1	Erythrocytosis Autosomal Dominant Benign
Familial Primary Polycythemia	Familial Erythrocytosis, 1
Erythrocytosis, Familial, Type 1

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136657	SC-43		99.02%	Unkown
HY-RS11429	PTPN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTPN6	VGNC	VGNC:69166
Rattus norvegicus	PTPN6	RGD	RGD:620660
Mus musculus	PTPN6	MGD	MGI:96055
Macaca mulatta	PTPN6	VGNC	VGNC:76607
Bos taurus	PTPN6	VGNC	VGNC:33541
Canis familiaris	PTPN6	VGNC	VGNC:45179
Others	PTPN6	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.