KRR1 - KRR1 small subunit processome component homolog Gene

Homo sapiens

Also known as HRB2; RIP-1

Gene ID: 11103 | Gene type: protein coding

About KRR1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,490,863-75,511,609 (from NCBI)

This gene has 5 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in appendix (RPKM 20.3), bone marrow (RPKM 19.6) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in chromosome; intercellular bridge; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

KRR1 Products(1)

mRNA	Protein	Name
NM_007043.7	NP_008974.5	KRR1 small subunit processome component homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19590578	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRR1 Protein Structure

KH_1

0
100
200
300
381 a.a.

Protein Preferred Names

Protein Names

KRR1 small subunit processome component homolog

HIV-1 Rev-binding protein 2

KRR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KRR1	Q13601	ZBP1	Homo sapiens	Q9H171	Anti Tag CoIP	19590578

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Duodenum Adenoma

Duodenal Benign Neoplasm

Neoplasm Of Duodenum	Neoplasm Of The Duodenum
Cancer Of Duodenum

Colorectal Cancer, Hereditary Nonpolyposis, Type 7

HNPCC7	Hereditary Nonpolyposis Colorectal Cancer Type 7
Hereditary Non-Polyposis Colorectal Cancer 7	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07432	KRR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KRR1	VGNC	VGNC:74182
Bos taurus	KRR1	VGNC	VGNC:30715
Felis catus	KRR1	VGNC	VGNC:67646
Rattus norvegicus	KRR1	RGD	RGD:1306183
Mus musculus	KRR1	MGD	MGI:1289274

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