PTPRT - protein tyrosine phosphatase receptor type T Gene

Homo sapiens

Also known as R-PTP-T; RPTPrho; RPTP-rho

Gene ID: 11122 | Gene type: protein coding

About PTPRT

Cytogenetic location: 20q12-q13.11 Genomic coordinates (GRCh38): 20:42,031,890-43,189,906 (from NCBI)

This gene has 12 transcripts (splice variants), 221 orthologues, 35 paralogues and is associated with 128 phenotypes. Biased expression in brain (RPKM 9.9) and placenta (RPKM 1.1).

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRT Products(5)

mRNA	Protein	Name
NM_001394024.1	NP_001380953.1	receptor-type tyrosine-protein phosphatase T isoform 3 precursor
NM_001394025.1	NP_001380954.1	receptor-type tyrosine-protein phosphatase T isoform 4 precursor
NM_001394026.1	NP_001380955.1	receptor-type tyrosine-protein phosphatase T isoform 5 precursor
NM_007050.6	NP_008981.4	receptor-type tyrosine-protein phosphatase T isoform 2 precursor
NM_133170.4	NP_573400.3	receptor-type tyrosine-protein phosphatase T isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables STAT family protein binding	IPI IPI: Inferred from physical interaction	17360477	GOA
enables alpha-catenin binding	IDA IDA: Inferred from direct assay	16973135	GOA
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	16973135	GOA
enables cadherin binding	IPI IPI: Inferred from physical interaction	16973135	GOA
enables delta-catenin binding	IPI IPI: Inferred from physical interaction	16973135	GOA
enables gamma-catenin binding	IDA IDA: Inferred from direct assay	16973135	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273344	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	24846175	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	24846175	GOA
enables protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	16973135	GOA
enables transmembrane receptor protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	24846175	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell surface receptor protein tyrosine kinase signaling pathway	IMP IMP: Inferred from mutant phenotype	16973135	GOA
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	17360477	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	18644975	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24846175	GOA
involved in negative regulation of receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	17360477	GOA
involved in negative regulation of receptor signaling pathway via STAT	IMP IMP: Inferred from mutant phenotype	24846175	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	17360477	GOA
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA IDA: Inferred from direct assay	24846175	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	16973135	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18644975	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18644975	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRT Protein Structure

MAM

fn3

Y_phosphatase

0
300
600
900
1200
1460 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase T

receptor protein tyrosine phosphatase

PTPRT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PTPRT	O14522	Nrxn1	Mus musculus	Q9CS84	Anti Bait CoIP	19816407
Cross	PTPRT	O14522	Nrxn1	Mus musculus	Q9CS84	Anti Tag CoIP	19816407
Intra	PTPRT	O14522	PTPRN	Homo sapiens	Q16849	Anti Tag CoIP	16273344
Cross	PTPRT	O14522	Nrxn3	Mus musculus	Q6P9K9	Anti Bait CoIP	19816407
Cross	PTPRT	O14522	Nlgn1	Mus musculus	Q99K10	Anti Bait CoIP	19816407

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11450	PTPRT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPRT	MGD	MGI:1321152
Macaca mulatta	PTPRT	VGNC	VGNC:76623
Bos taurus	PTPRT	VGNC	VGNC:57018
Felis catus	PTPRT	VGNC	VGNC:69182
Rattus norvegicus	PTPRT	RGD	RGD:1309653
Canis familiaris	PTPRT	VGNC	VGNC:45199

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