2. Gene
  3. NUDT4 - nudix hydrolase 4 Gene

NUDT4 - nudix hydrolase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DIPP2; NUDT4B; DIPP-2B; HDCMB47P; DIPP2beta; DIPP2alpha

Gene ID: 11163 | Gene type: protein coding

About NUDT4

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,377,925-93,408,146 (from NCBI)

This gene has 7 transcripts (splice variants), 294 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 30.0), kidney (RPKM 25.7) and 25 other tissues.

Summary

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each Other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

NUDT4 Products(5)

mRNA Protein Name
NM_001301022.2 NP_001287951.1 diphosphoinositol polyphosphate phosphohydrolase 2 isoform 3
NM_001301023.2 NP_001287952.1 diphosphoinositol polyphosphate phosphohydrolase 2 isoform 4
NM_001301024.2 NP_001287953.1 diphosphoinositol polyphosphate phosphohydrolase 2 isoform 4
NM_019094.6 NP_061967.3 diphosphoinositol polyphosphate phosphohydrolase 2 isoform alpha
NM_199040.4 NP_950241.1 diphosphoinositol polyphosphate phosphohydrolase 2 isoform beta
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables diphosphoinositol-polyphosphate diphosphatase activity IDA
IDA: Inferred from direct assay
10777568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT4 Protein Structure

NUDIX

NUDIX: NUDIX domain (21 - 133)

  • 0
  • 100
  • 180 a.a.
Protein Preferred Names Protein Names

diphosphoinositol polyphosphate phosphohydrolase 2

DIPP-2

NUDT4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NUDT4 Q9NZJ9 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
NUDT4 Q9NZJ9 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
NUDT4 Q9NZJ9 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
NUDT4 Q9NZJ9 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
NUDT4 Q9NZJ9 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
NUDT4 Q9NZJ9 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
NUDT4 Q9NZJ9 KEAP1 Homo sapiens Q14145
Validated Y2H
25416956
Intra
NUDT4 Q9NZJ9 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09672 NUDT4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NUDT4 MGD MGI:1918457
Rattus norvegicus NUDT4 RGD RGD:621355
Canis familiaris NUDT4 VGNC VGNC:58000