AKAP11 - A-kinase anchoring protein 11 Gene

Homo sapiens

Also known as PRKA11; AKAP-11; AKAP220; PPP1R44

Gene ID: 11215 | Gene type: protein coding

About AKAP11

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:42,271,477-42,323,261 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 22.2), testis (RPKM 15.0) and 24 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

AKAP11 Products(1)

mRNA	Protein	Name
NM_016248.4	NP_057332.1	A-kinase anchor protein 11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27484798	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 11

A kinase (PRKA) anchor protein 11

AKAP11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKAP11	Q9UKA4	LITAF	Homo sapiens	Q99732	Y2H Pooling	32814053
Intra	AKAP11	Q9UKA4	LITAF	Homo sapiens	Q99732	Validated Y2H	32814053
Intra	AKAP11	Q9UKA4	LITAF	Homo sapiens	Q99732	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 48

RP48	Retinitis Pigmentosa, Type 48

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00514	AKAP11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AKAP11	VGNC	VGNC:37753
Mus musculus	AKAP11	MGD	MGI:2684060
Bos taurus	AKAP11	VGNC	VGNC:25781
Felis catus	AKAP11	VGNC	VGNC:59712
Macaca mulatta	AKAP11	VGNC	VGNC:69765
Rattus norvegicus	AKAP11	RGD	RGD:2079

Name
Email *

	Sorry, but the email address you supplied was invalid.