RNF24 - ring finger protein 24 Gene

Homo sapiens

Also known as G1L

Gene ID: 11237 | Gene type: protein coding

About RNF24

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,927,311-4,015,558 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 12.4), brain (RPKM 5.0) and 23 other tissues.

Summary

This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]

RNF24 Products(4)

mRNA	Protein	Name
NM_001134337.3	NP_001127809.1	RING finger protein 24 isoform 1
NM_001134338.3	NP_001127810.1	RING finger protein 24 isoform 2
NM_001321749.2	NP_001308678.1	RING finger protein 24 isoform 1
NM_007219.5	NP_009150.1	RING finger protein 24 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF24 Protein Structure

zf-RING_2

0
100
148 a.a.

Protein Preferred Names

Protein Names

RING finger protein 24

RNF24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF24	Q9Y225	UQCRH	Homo sapiens	P07919	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schopf-Schulz-Passarge Syndrome

SSPS	Eccrine Tumors With Ectodermal Dysplasia
Eccrine Tumors-Ectodermal Dysplasia	Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome	Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome
Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis	Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis

Pasteurellosis

Pasteurella Infection	Pasteurella Infections
Pasteurella Infectious Disease	Shipping Fever
Transport Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12083	RNF24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RNF24	VGNC	VGNC:45664
Mus musculus	RNF24	MGD	MGI:1261771
Rattus norvegicus	RNF24	RGD	RGD:1309384
Bos taurus	RNF24	VGNC	VGNC:34059
Macaca mulatta	RNF24	VGNC	VGNC:76729

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