MGAT4B - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Gene

Homo sapiens

Also known as GNT-IV; GNT-IVB

Gene ID: 11282 | Gene type: protein coding

About MGAT4B

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,797,597-179,806,866 (from NCBI)

This gene has 23 transcripts (splice variants), 1 gene allele, 212 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 64.0), duodenum (RPKM 63.6) and 24 other tissues.

Summary

This gene encodes a key Glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

MGAT4B Products(2)

mRNA	Protein	Name
NM_014275.5	NP_055090.1	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 1 precursor
NM_054013.3	NP_463459.1	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	10372966	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein glycosylation	IDA IDA: Inferred from direct assay	17006639	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT4B Protein Structure

Glyco_transf_54

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

N-acetylglucosaminyltransferase IVb

MGAT4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MGAT4B	Q9UQ53	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	MGAT4B	Q9UQ53	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Iia

CDG2A	Congenital Disorder Of Glycosylation Type Iia
Cdg Iia	Cdgiia
Congenital Disorder Of Glycosylation Type 2a	Alkuraya Syndrome
Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth	Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii
Mgat2-Cdg	Cdg-Iia
Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly	Cdgs2, Formerly
Cdgs2	Cdg Syndrome Type Iia
Carbohydrate Deficient Glycoprotein Syndrome Type Iia	N-Acetylglucosaminyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2a	Carbohydrate-Deficient Glycoprotein Syndrome Type Ii
Cdgs Type Ii	Carbohydrate-Deficient Glycoprotein Syndrome Type 2
Glycosylation, Congenital Disorder Of, Type Iia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70286	N-Acetylglucosaminyltransferase V		/	Unkown
HY-RS08405	MGAT4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MGAT4B	RGD	RGD:1562836
Mus musculus	MGAT4B	MGD	MGI:2143974
Bos taurus	MGAT4B	VGNC	VGNC:54624
Canis familiaris	MGAT4B	VGNC	VGNC:51745
Felis catus	MGAT4B	VGNC	VGNC:68248
Macaca mulatta	MGAT4B	VGNC	VGNC:74715

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