APPBP2 - amyloid beta precursor protein binding protein 2 Gene

Homo sapiens

Also known as PAT1; APP-BP2; HS.84084

Gene ID: 10513 | Gene type: protein coding

About APPBP2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:60,443,158-60,526,242 (from NCBI)

This gene has 6 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 16.4), brain (RPKM 11.4) and 25 other tissues.

Summary

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

APPBP2 Products(2)

mRNA	Protein	Name
NM_001282476.2	NP_001269405.1	amyloid protein-binding protein 2 isoform 2
NM_006380.5	NP_006371.2	amyloid protein-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	26138980	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intracellular transport	IDA IDA: Inferred from direct assay	9843960	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	26138980	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	26138980	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	9843960	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APPBP2 Protein Structure

TPR_12

TPR_10

0
100
200
300
400
500
585 a.a.

Protein Preferred Names

Protein Names

amyloid protein-binding protein 2

amyloid beta precursor protein (cytoplasmic tail) binding protein 2

APPBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APPBP2	Q92624	HEL-S-72	Homo sapiens	B4DJ51	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ST8SIA5	Homo sapiens	O15466	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ST8SIA5	Homo sapiens	O15466	Validated Y2H	25416956
Intra	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
Intra	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Y2H Array	25416956
Intra	APPBP2	Q92624	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	FXYD7	Homo sapiens	P58549	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	FXYD7	Homo sapiens	P58549	Validated Y2H	25416956
Intra	APPBP2	Q92624	SELENOV	Homo sapiens	P59797	Validated Y2H	25416956
Intra	APPBP2	Q92624	SELENOV	Homo sapiens	P59797	Y2H Array	25416956
Intra	APPBP2	Q92624	C6orf226	Homo sapiens	Q5I0X4	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	C6orf226	Homo sapiens	Q5I0X4	Y2H Array	25416956
Intra	APPBP2	Q92624	ARMCX5	Homo sapiens	Q6P1M9	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ANKRD10	Homo sapiens	Q8IUW1	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ANKRD10	Homo sapiens	Q8IUW1	Validated Y2H	25416956
Intra	APPBP2	Q92624	GCSAM	Homo sapiens	Q8N6F7	Validated Y2H	25416956
Intra	APPBP2	Q92624	GCSAM	Homo sapiens	Q8N6F7	Y2H Array	25416956
Intra	APPBP2	Q92624	TAF11	Homo sapiens	Q15544	Validated Y2H	25416956
Intra	APPBP2	Q92624	TAF11	Homo sapiens	Q15544	Y2H Array	25416956
Intra	APPBP2	Q92624	TAFA4	Homo sapiens	Q96LR4	Validated Y2H	25416956
Intra	APPBP2	Q92624	TAFA4	Homo sapiens	Q96LR4	Y2H Array	25416956
Intra	APPBP2	Q92624	PCTK1	Homo sapiens	Q9BRL4	Y2H Array	25416956
Intra	APPBP2	Q92624	C16orf35	Homo sapiens	Q9BTE2	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ANKRD10	Homo sapiens	Q9NXR5	Validated Y2H	25416956
Intra	APPBP2	Q92624	AHCY	Homo sapiens	P23526	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Y2H Array	25416956
Intra	APPBP2	Q92624	UGGT2	Homo sapiens	Q9NYU1	Validated Y2H	25416956
Intra	APPBP2	Q92624	SLC7A10	Homo sapiens	Q9NS82	Validated Y2H	32296183
Intra	APPBP2	Q92624	ATP13A1	Homo sapiens	Q9HD20-3	Validated Y2H	32296183
Intra	APPBP2	Q92624	SNX5	Homo sapiens	Q9Y5X3-2	Validated Y2H	32296183
Intra	APPBP2	Q92624	MAN2B2	Homo sapiens	Q9Y2E5	Validated Y2H	32296183
Intra	APPBP2	Q92624	SYNRG	Homo sapiens	Q9UMZ2-8	Validated Y2H	32296183
Intra	APPBP2	Q92624	BIN2	Homo sapiens	Q9UBW5	Validated Y2H	32296183
Intra	APPBP2	Q92624	RNF34	Homo sapiens	Q969K3	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	RNF34	Homo sapiens	Q969K3	Y2H Array	25416956
Intra	APPBP2	Q92624	UBE2R2	Homo sapiens	Q712K3	Validated Y2H	25416956
Intra	APPBP2	Q92624	RNF128	Homo sapiens	Q8TEB7	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Array	19060904
Intra	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Pooling	19060904
Intra	APPBP2	Q92624	FSTL1	Homo sapiens	Q12841	Y2H Array	25416956
Intra	APPBP2	Q92624	WFIKKN1	Homo sapiens	Q96NZ8	Validated Y2H	32296183
Intra	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Validated Y2H	32296183
Intra	APPBP2	Q92624	LANCL2	Homo sapiens	Q9NS86	Y2H Array	25416956
Intra	APPBP2	Q92624	CTC1	Homo sapiens	Q2NKJ3	Validated Y2H	25416956
Intra	APPBP2	Q92624	CTC1	Homo sapiens	Q2NKJ3	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ERO1A	Homo sapiens	Q96HE7	Y2H Array	25416956
Intra	APPBP2	Q92624	ERO1A	Homo sapiens	Q96HE7	Validated Y2H	25416956
Intra	APPBP2	Q92624	PRKACB	Homo sapiens	P22694	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	PRKACB	Homo sapiens	P22694	Y2H Array	25416956
Intra	APPBP2	Q92624	LONRF3	Homo sapiens	Q496Y0	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	LONRF3	Homo sapiens	Q496Y0	Y2H Array	25416956
Intra	APPBP2	Q92624	CCNL1	Homo sapiens	Q9UK58	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	CCNL1	Homo sapiens	Q9UK58	Validated Y2H	25416956
Intra	APPBP2	Q92624	C1orf50	Homo sapiens	Q9BV19	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	C1orf50	Homo sapiens	Q9BV19	Validated Y2H	32296183
Intra	APPBP2	Q92624	SLC25A23	Homo sapiens	Q9BV35	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	SLC25A23	Homo sapiens	Q9BV35	Validated Y2H	25416956
Intra	APPBP2	Q92624	WAS	Homo sapiens	P42768	Y2H Array	25416956
Intra	APPBP2	Q92624	WAS	Homo sapiens	P42768	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
Intra	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	32296183
Intra	APPBP2	Q92624	GSTP1	Homo sapiens	P09211	Y2H Array	25416956
Intra	APPBP2	Q92624	GSTP1	Homo sapiens	P09211	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	DHRS2	Homo sapiens	Q13268	Validated Y2H	25416956
Intra	APPBP2	Q92624	HSPA4	Homo sapiens	P34932	Validated Y2H	25416956
Intra	APPBP2	Q92624	HSPA4	Homo sapiens	P34932	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	NFYA	Homo sapiens	P23511	Y2H Pooling	19060904
Intra	APPBP2	Q92624	NFYA	Homo sapiens	P23511	Y2H Array	19060904
Intra	APPBP2	Q92624	AK3	Homo sapiens	Q9UIJ7	Validated Y2H	32296183
Intra	APPBP2	Q92624	AK3	Homo sapiens	Q9UIJ7	Y2H Array	25416956
Intra	APPBP2	Q92624	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	APPBP2	Q92624	RAB7B	Homo sapiens	Q96AH8	Validated Y2H	32296183
Intra	APPBP2	Q92624	DCD	Homo sapiens	P81605	Y2H Array	25416956
Intra	APPBP2	Q92624	DCD	Homo sapiens	P81605	Validated Y2H	25416956
Intra	APPBP2	Q92624	ZNF747	Homo sapiens	Q9BV97	Validated Y2H	25416956
Intra	APPBP2	Q92624	ZNF747	Homo sapiens	Q9BV97	Y2H Array	25416956
Intra	APPBP2	Q92624	HIPK4	Homo sapiens	Q8NE63	Validated Y2H	25416956
Intra	APPBP2	Q92624	HIPK4	Homo sapiens	Q8NE63	Y2H Array	25416956
Intra	APPBP2	Q92624	SNX5	Homo sapiens	Q9Y5X3	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	TBL3	Homo sapiens	Q12788	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	TBL3	Homo sapiens	Q12788	Y2H Pooling	16189514
Intra	APPBP2	Q92624	PPP1R8	Homo sapiens	Q12972	Validated Y2H	25416956
Intra	APPBP2	Q92624	MCOLN1	Homo sapiens	Q9GZU1	Validated Y2H	32296183
Intra	APPBP2	Q92624	CORO2B	Homo sapiens	Q9UQ03	Validated Y2H	32296183
Intra	APPBP2	Q92624	CORO2B	Homo sapiens	Q9UQ03	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	SYNRG	Homo sapiens	Q9UMZ2	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	MGAT4B	Homo sapiens	Q9UQ53	Validated Y2H	32296183
Intra	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Validated Y2H	25416956
Intra	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Y2H Array	25416956
Intra	APPBP2	Q92624	CDK16	Homo sapiens	Q00536	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	ZC3H10	Homo sapiens	Q96K80	Y2H Array	25416956
Intra	APPBP2	Q92624	ZC3H10	Homo sapiens	Q96K80	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Array	19060904
Intra	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Pooling	19060904
Intra	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Y2H Pooling	16189514
Intra	APPBP2	Q92624	MUL1	Homo sapiens	Q969V5	Validated Y2H	32296183
Intra	APPBP2	Q92624	TCF25	Homo sapiens	Q9BQ70	Validated Y2H	25416956
Intra	APPBP2	Q92624	WDR24	Homo sapiens	Q96S15	Y2H Pooling	16189514
Intra	APPBP2	Q92624	WDR24	Homo sapiens	Q96S15	Validated Y2H	25416956
Intra	APPBP2	Q92624	RRS1	Homo sapiens	Q15050	Y2H Pooling	16189514
Intra	APPBP2	Q92624	DPEP1	Homo sapiens	P16444	Y2H Array	25416956
Intra	APPBP2	Q92624	SLC22A6	Homo sapiens	Q4U2R8	Y2H Array	19060904
Intra	APPBP2	Q92624	SLC22A6	Homo sapiens	Q4U2R8	Y2H Pooling	19060904
Intra	APPBP2	Q92624	SELI	Homo sapiens	Q8WU57	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	SELI	Homo sapiens	Q8WU57	Y2H Array	25416956
Intra	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Pooling	19060904
Intra	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Pooling	16189514
Intra	APPBP2	Q92624	SYT11	Homo sapiens	Q9BT88	Y2H Array	19060904
Intra	APPBP2	Q92624	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183
Intra	APPBP2	Q92624	CCDC167	Homo sapiens	Q9P0B6	Validated Y2H	32296183
Intra	APPBP2	Q92624	KLHL35	Homo sapiens	Q6PF15	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	KLF11	Homo sapiens	O14901	Y2H Prey Pooling	25416956
Intra	APPBP2	Q92624	KLF11	Homo sapiens	O14901	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Clear Cell Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00866	APPBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APPBP2	VGNC	VGNC:69991
Canis familiaris	APPBP2	VGNC	VGNC:38011
Bos taurus	APPBP2	VGNC	VGNC:26039
Felis catus	APPBP2	VGNC	VGNC:67891
Rattus norvegicus	APPBP2	RGD	RGD:1306488
Mus musculus	APPBP2	MGD	MGI:1914134

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