PTH2 - parathyroid hormone 2 Gene

Homo sapiens

Also known as TIP39

Gene ID: 113091 | Gene type: protein coding

About PTH2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,422,419-49,423,441 (from NCBI)

This gene has 1 transcript (splice variant) and 150 orthologues.

Summary

This gene encodes the precursor of a peptide hormone that shares sequence similarity with the parathyroid hormone. This gene is expressed in various regions of the brain where it plays a role in the release of pituitary Hormones, anxiety and nociception. The encoded precursor protein is proteolytically processed to generate the biologically active neuropeptide. [provided by RefSeq, Jul 2015]

PTH2 Products(1)

mRNA	Protein	Name
NM_178449.4	NP_848544.1	tuberoinfundibular peptide of 39 residues preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTH2 Protein Structure

TIP39

0
100 a.a.

Protein Preferred Names

Protein Names

tuberoinfundibular peptide of 39 residues

tuberoinfundibular 39 residue protein

Related Diseases

Diseases

Alias

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Benign Chronic Pemphigus

Hailey-Hailey Disease	Pemphigus, Benign Familial
Familial Benign Pemphigus	Benign Familial Pemphigus
Familial Benign Chronic Pemphigus	BCPM
HHD	Benign Chronic Familial Pemphigus Of Hailey-Hailey
Pemphigus, Chronic, Benign

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1852	TIP 39, Tuberoinfundibular Neuropeptide	Activator	99.84%	Unkown
HY-RS11396	PTH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11397	PTH2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTH2	VGNC	VGNC:64429
Rattus norvegicus	PTH2	RGD	RGD:1559447
Bos taurus	PTH2	VGNC	VGNC:33515
Mus musculus	PTH2	MGD	MGI:2152297
Canis familiaris	PTH2	VGNC	VGNC:45155
Macaca mulatta	PTH2	VGNC	VGNC:76577

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