LYPLA2 - lysophospholipase 2 Gene

Homo sapiens

Also known as APT2; APT-2; DJ886K2.4

Gene ID: 11313 | Gene type: protein coding

About LYPLA2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,791,145-23,795,539 (from NCBI)

This gene has 10 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues.

Summary

Lysophospholipases are Enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

LYPLA2 Products(1)

mRNA	Protein	Name
NM_007260.3	NP_009191.1	acyl-protein thioesterase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	25301951	GOA
enables palmitoyl-(protein) hydrolase activity	IDA IDA: Inferred from direct assay	28826475	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	25301951	GOA
involved in prostaglandin catabolic process	IDA IDA: Inferred from direct assay	25301951	GOA
involved in protein depalmitoylation	IDA IDA: Inferred from direct assay	28826475	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYPLA2 Protein Structure

Abhydrolase_2

0
100
200
231 a.a.

Protein Preferred Names

Protein Names

acyl-protein thioesterase 2

LPL-II

Recombinant LYPLA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70221	Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His)	O95372 (M1-V231)	≥95%

Related Diseases

Diseases

Alias

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100736	ML348	Inhibitor	99.96%	Unkown
HY-100737	ML349	Inhibitor	99.40%	Unkown
HY-128035	ML-211	Inhibitor	98.06%	Unkown
HY-RS07922	LYPLA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LYPLA2	MGD	MGI:1347000
Macaca mulatta	LYPLA2	VGNC	VGNC:74465
Canis familiaris	LYPLA2	VGNC	VGNC:42891
Felis catus	LYPLA2	VGNC	VGNC:68112
Bos taurus	LYPLA2	VGNC	VGNC:31106
Rattus norvegicus	LYPLA2	RGD	RGD:620210
Others	LYPLA2	NCBI

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