2. Gene
  3. INCA1 - inhibitor of CDK, cyclin A1 interacting protein 1 Gene

INCA1 - inhibitor of CDK, cyclin A1 interacting protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HSD45

Gene ID: 388324 | Gene type: protein coding

About INCA1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,988,130-4,997,522 (from NCBI)

This gene has 5 transcripts (splice variants) and 86 orthologues. Broad expression in testis (RPKM 10.5), prostate (RPKM 1.7) and 21 other tissues.

Summary

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

INCA1 Products(8)

mRNA Protein Name
NM_001167985.2 NP_001161457.1 protein INCA1 isoform 2
NM_001167986.2 NP_001161458.1 protein INCA1 isoform 1
NM_001167987.2 NP_001161459.1 protein INCA1 isoform 1
NM_001394788.1 NP_001381717.1 protein INCA1 isoform 1
NM_001394789.1 NP_001381718.1 protein INCA1 isoform 1
NM_001394790.1 NP_001381719.1 protein INCA1 isoform 2
NM_001394791.1 NP_001381720.1 protein INCA1 isoform 2
NM_213726.3 NP_998891.2 protein INCA1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cyclin binding IDA
IDA: Inferred from direct assay
21540187 GOA
enables cyclin binding IPI
IPI: Inferred from physical interaction
15159402 GOA
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
21540187 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18756329 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15159402 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21540187 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18756329 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15159402 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INCA1 Protein Structure

INCA1

INCA1: INCA1 (12 - 190)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

protein INCA1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06804 INCA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INCA1 VGNC VGNC:30193
Rattus norvegicus INCA1 RGD RGD:1306656
Macaca mulatta INCA1 VGNC VGNC:73691
Mus musculus INCA1 MGD MGI:2144284
Felis catus INCA1 VGNC VGNC:62921
Canis familiaris INCA1 VGNC VGNC:42015