ODF3 - outer dense fiber of sperm tails 3 Gene

Homo sapiens

Also known as CT135; TISP50; SHIPPO1

Gene ID: 113746 | Gene type: protein coding

About ODF3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:196,761-200,258 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 3.9).

Summary

ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement.[supplied by OMIM, Apr 2004]

ODF3 Products(2)

mRNA	Protein	Name
NM_001286136.2	NP_001273065.1	outer dense fiber protein 3 isoform 2
NM_053280.5	NP_444510.2	outer dense fiber protein 3 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23355646	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ODF3 Protein Structure

SHIPPO-rpt

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

outer dense fiber protein 3

cancer/testis antigen 135

ODF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIMAP1A	Q96PU9	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	CIMAP1A	Q96PU9	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	CIMAP1A	Q96PU9	HOGA1	Homo sapiens	Q86XE5	Y2H Prey Pooling	32296183
Intra	CIMAP1A	Q96PU9	HOGA1	Homo sapiens	Q86XE5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Salpingitis

Chronic Salpingitis

Pyosalpinx

Pyosalpingitis

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09753	ODF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ODF3	VGNC	VGNC:44101
Bos taurus	ODF3	VGNC	VGNC:32403
Macaca mulatta	ODF3	VGNC	VGNC:75438
Rattus norvegicus	ODF3	RGD	RGD:1310028
Felis catus	ODF3	VGNC	VGNC:63950
Mus musculus	ODF3	MGD	MGI:1916537

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