2. Gene
  3. HENMT1 - HEN methyltransferase 1 Gene

HENMT1 - HEN methyltransferase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEN1; C1orf59

Gene ID: 113802 | Gene type: protein coding

About HENMT1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:108,648,295-108,661,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 199 orthologues. Biased expression in testis (RPKM 38.3), lymph node (RPKM 5.6) and 13 other tissues.

Summary

Enables small RNA 2'-O-methyltransferase. Involved in RNA methylation. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HENMT1 Products(2)

mRNA Protein Name
NM_001102592.2 NP_001096062.1 small RNA 2'-O-methyltransferase
NM_144584.3 NP_653185.2 small RNA 2'-O-methyltransferase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22458338 GOA
enables small RNA 2'-O-methyltransferase activity IDA
IDA: Inferred from direct assay
11283698 GOA
Biological Process GO Annotation Evidence Reference Source
involved in RNA methylation IDA
IDA: Inferred from direct assay
11283698 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HENMT1 Protein Structure

Methyltransf_23

Methyltransf_23: Methyltransferase domain (35 - 191)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

small RNA 2'-O-methyltransferase

HEN1 methyltransferase homolog 1

Related Diseases

Diseases Alias
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06121 HENMT1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HENMT1 VGNC VGNC:73241
Bos taurus HENMT1 VGNC VGNC:29809
Mus musculus HENMT1 MGD MGI:1913965
Rattus norvegicus HENMT1 RGD RGD:1306230
Felis catus HENMT1 VGNC VGNC:62795
Canis familiaris HENMT1 VGNC VGNC:41656