Vegfc - vascular endothelial growth factor C Gene

Rattus norvegicus

Gene ID: 114111 | Gene type: protein coding

About Vegfc

Summary

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C). [provided by Alliance of Genome Resources, Apr 2022]

Vegfc Products(1)

mRNA	Protein	Name
NM_053653.2	NP_446105.1	vascular endothelial growth factor C precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables vascular endothelial growth factor receptor 3 binding	IMP IMP: Inferred from mutant phenotype	11683876	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	12706123	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	19412173	RGD
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	12706123	RGD
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16462734	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16618418	RGD
acts upstream of or within positive regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	16462734	RGD
involved in positive regulation of protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	11683876	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	16618418	RGD
involved in regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11683876	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19147132	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vascular endothelial growth factor C

VEGF-C	VRP
flt4 ligand	flt4-L
vascular endothelial growth factor-related protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase Phase 2
HY-P3369	Gersizangitide		98.05%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 1
HY-P990675	VGX-100	Inhibitor	99.54%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-N2187	Deoxyshikonin		99.96%	Unkown
HY-RS15637	VEGFC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect Antagonist	Purity	Rare Diseases Unkown
HY-P9920A	Ramucirumab (anti-VEGFR)	Antagonist	99.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vegfc	NCBI	NCBI:7424
Mus musculus	Vegfc	NCBI	NCBI:22341

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