Vegfc - vascular endothelial growth factor C Gene

Mus musculus

Also known as VEGF-C

Gene ID: 22341 | Gene type: protein coding

About Vegfc

Summary

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of angiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C). [provided by Alliance of Genome Resources, Apr 2022]

Vegfc Products(1)

mRNA	Protein	Name
NM_009506.2	NP_033532.1	vascular endothelial growth factor C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25752543	MGI
enables vascular endothelial growth factor receptor 3 binding	IPI IPI: Inferred from physical interaction	9012504	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	14634646	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16462734	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	16462734	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	14634646	MGI
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	26934950	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	24552833	MGI
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	26934950	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	9247316	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16462734	MGI
acts upstream of or within positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	16462734	MGI
acts upstream of or within positive regulation of lymphangiogenesis	IDA IDA: Inferred from direct assay	20133819	MGI
involved in positive regulation of lymphangiogenesis	IDA IDA: Inferred from direct assay	24552833	MGI
involved in positive regulation of mesenchymal stem cell proliferation	IDA IDA: Inferred from direct assay	26934950	MGI
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	26934950	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	9012504	MGI
involved in vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	24552833	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	9247316	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	9247316	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vascular endothelial growth factor C

VRP	flt4 ligand
flt4-L	vascular endothelial growth factor-related protein

Recombinant Vegfc Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74474	VEGF-CC Protein, Mouse/Rat (HEK293, His)	P97953/NP_033532.1/O35757 (A108-R223)	≥95%
HY-P74475	VEGF-CC Protein, Mouse/Rat (HEK293, Fc)	P97953 (A108-R223)/O35757(A108-R223)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3369	Gersizangitide		98.05%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990675	VGX-100	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2187	Deoxyshikonin		99.96%	Unkown
HY-RS15637	VEGFC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9920A	Ramucirumab (anti-VEGFR)	Antagonist	99.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vegfc	NCBI	NCBI:7424
Rattus norvegicus	Vegfc	NCBI	NCBI:114111

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