Ace - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene

Mus musculus

Also known as CD143

Gene ID: 11421 | Gene type: protein coding

About Ace

Chromosome 11: 105,858,771-105,880,790 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 94 orthologues, 2 paralogues and is associated with 88 phenotypes. Biased expression in lung adult (RPKM 34.6), duodenum adult (RPKM 225.6) and 6 other tissues.

Summary

Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting Enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ace Products(3)

mRNA	Protein	Name
NM_009598.3	NP_033728.1	angiotensin-converting enzyme isoform 2 precursor
NM_207624.6	NP_997507.1	angiotensin-converting enzyme isoform 1 precursor
NM_001281819.2	NP_001268748.1	angiotensin-converting enzyme isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	11303049	MGI
enables peptidase activity	IMP IMP: Inferred from mutant phenotype	9231832	MGI
enables peptidyl-dipeptidase activity	IDA IDA: Inferred from direct assay	11303049	MGI
enables peptidyl-dipeptidase activity	IMP IMP: Inferred from mutant phenotype	16270063	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23055941	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiotensin maturation	IDA IDA: Inferred from direct assay	11303049	MGI
involved in angiotensin maturation	IMP IMP: Inferred from mutant phenotype	14757757	MGI
involved in angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	20116413	MGI
acts upstream of or within heart contraction	IMP IMP: Inferred from mutant phenotype	16585392	MGI
involved in hormone catabolic process	IDA IDA: Inferred from direct assay	11303049	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17135368	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	11723129	MGI
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	11723129	MGI
involved in negative regulation of gap junction assembly	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within neutrophil mediated immunity	IMP IMP: Inferred from mutant phenotype	17082641	MGI
involved in positive regulation of peptidyl-cysteine S-nitrosylation	IMP IMP: Inferred from mutant phenotype	25017399	MGI
acts upstream of or within positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	9231832	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	11303049	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	11723129	MGI
involved in regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	25017399	MGI
involved in regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	20116413	MGI
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	35201898	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	17135368	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23535237	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	23535237	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ace Protein Structure

Peptidase_M2

0
300
600
900
1200
1312 a.a.

Protein Preferred Names

Protein Names

angiotensin-converting enzyme

dipeptidyl carboxypeptidase I	dipeptidyl peptidase
kininase II

Ace Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82349	ACE Antibody (YA2094)	WB, IHC-P	Mouse, Rat

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123381	Gemopatrilat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4281	Ovotransferrin (328-332)	Inhibitor	/	Unkown
HY-P10601	αs1-CN f(143–149)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ace	NCBI	NCBI:1636
Canis familiaris	Ace	NCBI	NCBI:610668
Macaca fascicularis	Ace	NCBI
Susscrofa domestica	Ace	NCBI
Rattus norvegicus	Ace	NCBI	NCBI:24310
Macaca mulatta	Ace	NCBI	NCBI:100428661

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