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  3. Ace - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene

Ace - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD143

Gene ID: 11421 | Gene type: protein coding

About Ace

Chromosome 11: 105,858,771-105,880,790 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 94 orthologues, 2 paralogues and is associated with 88 phenotypes. Biased expression in lung adult (RPKM 34.6), duodenum adult (RPKM 225.6) and 6 other tissues.

Summary

Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting Enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ace Products(3)

mRNA Protein Name
NM_009598.3 NP_033728.1 angiotensin-converting enzyme isoform 2 precursor
NM_207624.6 NP_997507.1 angiotensin-converting enzyme isoform 1 precursor
NM_001281819.2 NP_001268748.1 angiotensin-converting enzyme isoform 3 precursor

Ace Protein Structure

Peptidase_M2

Peptidase_M2: pfam01401 (44 - 627)

Peptidase_M2

Peptidase_M2: pfam01401 (648 - 1225)

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  • 1312 a.a.
Protein Preferred Names Protein Names

angiotensin-converting enzyme

dipeptidyl carboxypeptidase I

dipeptidyl peptidase

kininase II

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-123381 Gemopatrilat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P4281 Ovotransferrin (328-332) Inhibitor / Unkown
HY-P10601 αs1-CN f(143–149) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ace NCBI NCBI:1636
Canis familiaris Ace NCBI NCBI:610668
Macaca fascicularis Ace NCBI
Susscrofa domestica Ace NCBI
Rattus norvegicus Ace NCBI NCBI:24310
Macaca mulatta Ace NCBI NCBI:100428661