ACE - angiotensin I converting enzyme Gene

Rattus norvegicus

Also known as Dcp1; CD143; StsRR92

Gene ID: 24310 | Gene type: protein coding

About ACE

Primary_assembly 10: 90,910,316-90,931,131 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 94 orthologues, 2 paralogues and is associated with 184 phenotypes. Biased expression in Lung (RPKM 989.5), Testes (RPKM 175.9) and 2 other tissues.

Summary

Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including animal organ development; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system Cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting Enzyme). [provided by Alliance of Genome Resources, Apr 2022]

ACE Products(1)

mRNA	Protein	Name
NM_012544.1	NP_036676.1	angiotensin-converting enzyme precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	7620708	RGD
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	11299220	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	12500972	RGD
enables peptidyl-dipeptidase activity	IDA IDA: Inferred from direct assay	8292044	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	22123369	RGD
involved in animal organ regeneration	IMP IMP: Inferred from mutant phenotype	22441330	RGD
involved in bradykinin catabolic process	IDA IDA: Inferred from direct assay	2172462	RGD
involved in bradykinin catabolic process	IMP IMP: Inferred from mutant phenotype	11299220	RGD
involved in cellular response to aldosterone	IEP IEP: Inferred from expression pattern	11447075	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	17626897	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	19361967	RGD
involved in embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	1784836	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17977916	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	7977726	RGD
involved in lung alveolus development	IMP IMP: Inferred from mutant phenotype	22587910	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	7977726	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	7977726	RGD
involved in negative regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	24184594	RGD
involved in negative regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	10506486	RGD
involved in peptide catabolic process	IDA IDA: Inferred from direct assay	16148611	RGD
involved in peptide metabolic process	IMP IMP: Inferred from mutant phenotype	10642323	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19301230	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17161436	RGD
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	20122169	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	10506486	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17161436	RGD
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	1750504	RGD
involved in regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	1750504	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	1659346	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14527966	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	9048650	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19114890	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	18389998	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	1659346	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9495881	RGD
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	20204775	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	2841539	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	2827504	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	19307186	RGD
located in sperm midpiece	IDA IDA: Inferred from direct assay	12444051	RGD
located in vesicle	IDA IDA: Inferred from direct assay	2841539	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACE Protein Structure

Peptidase_M2

0
300
600
900
1200
1313 a.a.

Protein Preferred Names

Protein Names

angiotensin-converting enzyme

Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)	angiotensin 1 converting enzyme 1
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	angiotensin I converting enzyme 1
angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)	angiotensin-converting enzyme-like
dipeptidyl carboxypeptidase I	kininase II

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-123381	Gemopatrilat	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4281	Ovotransferrin (328-332)	Inhibitor	/	Unkown
HY-P10601	αs1-CN f(143–149)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ACE	NCBI	NCBI:1636
Canis familiaris	ACE	NCBI	NCBI:610668
Macaca fascicularis	ACE	NCBI
Mus musculus	ACE	NCBI	NCBI:11421
Susscrofa domestica	ACE	NCBI
Macaca mulatta	ACE	NCBI	NCBI:100428661

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