2. Gene
  3. Mtnr1a - melatonin receptor 1A Gene

Mtnr1a - melatonin receptor 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 114211 | Gene type: protein coding

About Mtnr1a

Primary_assembly 16: 47,144,461-47,163,919 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 185 orthologues, 50 paralogues and is associated with 7 phenotypes. Biased expression in Uterus (RPKM 4.2), Adrenal (RPKM 1.1) and 1 other tissue.

Summary

Predicted to enable hormone binding activity; Melatonin Receptor activity; and organic cyclic compound binding activity. Involved in several processes, including camera-type eye development; circadian rhythm; and negative regulation of Insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (Melatonin Receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Mtnr1a Products(1)

mRNA Protein Name
NM_053676.2 NP_446128.1 melatonin receptor type 1A
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in camera-type eye development IEP
IEP: Inferred from expression pattern
12890503 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
23895529 RGD
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22288848 RGD
Cellular Component GO Annotation Evidence Reference Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
10465462 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mtnr1a Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (30 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (32 - 56)

7tm_GPCRs

7tm_GPCRs: cd14964 (65 - 87)

7tm_GPCRs

7tm_GPCRs: cd14964 (103 - 125)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (187 - 210)

7tm_GPCRs

7tm_GPCRs: cd14964 (239 - 261)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

melatonin receptor type 1A

mel-1A-R

mel1a melatonin receptor

mel1a receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145700 UCSF648 / Unkown
HY-RS08803 MTNR1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08804 Mtnr1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08805 Mtnr1a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtnr1a NCBI NCBI:4543