MTNR1A - melatonin receptor 1A Gene

Homo sapiens

Also known as MT1; MEL-1A-R

Gene ID: 4543 | Gene type: protein coding

About MTNR1A

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,533,655-186,555,567 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 33 paralogues. Biased expression in kidney (RPKM 1.1), testis (RPKM 0.6) and 8 other tissues.

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A Products(2)

mRNA	Protein	Name
NM_005958.4	NP_005949.1	melatonin receptor type 1A
XM_011532002.4	XP_011530304.1	melatonin receptor type 1A isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone binding	IPI IPI: Inferred from physical interaction	10531408	GOA
enables melatonin receptor activity	IDA IDA: Inferred from direct assay	10531408	GOA
enables organic cyclic compound binding	IPI IPI: Inferred from physical interaction	10531408	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17215244	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10531408	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10531408	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	10531408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTNR1A Protein Structure

7tm_1

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

melatonin receptor type 1A

mel1a receptor

MTNR1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTNR1A	P48039	TMEM33	Homo sapiens	P57088	TAP	17215244
Intra	MTNR1A	P48039	TMEM33	Homo sapiens	P57088	TAP	26514267
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	Ub Reconstruction	28298427
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	TAP	17215244
Intra	MTNR1A	P48039	CALR	Homo sapiens	P27797	TAP	26514267
Intra	MTNR1A	P48039	RGS20	Homo sapiens	O76081	Pull Down	20859254
Intra	MTNR1A	P48039	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	MTNR1A	P48039	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	MTNR1A	P48039	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MTNR1A	P48039	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Deafness, Autosomal Dominant 24

DFNA24	Autosomal Dominant Nonsyndromic Deafness 24
Autosomal Dominant Deafness 24

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Scoliosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145700	UCSF648		/	Unkown
HY-RS08803	MTNR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08804	Mtnr1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08805	Mtnr1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTNR1A	VGNC	VGNC:31746
Canis familiaris	MTNR1A	VGNC	VGNC:110519
Mus musculus	MTNR1A	MGD	MGI:102967
Rattus norvegicus	MTNR1A	RGD	RGD:620797
Macaca mulatta	MTNR1A	VGNC	VGNC:81477
Felis catus	MTNR1A	VGNC	VGNC:78528

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