Chrna1 - cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) Gene

Mus musculus

Also known as Acra; Achr-1

Gene ID: 11435 | Gene type: protein coding

About Chrna1

Summary

This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]

Chrna1 Products(1)

mRNA	Protein	Name
NM_007389.5	NP_031415.2	acetylcholine receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to acetylcholine binding	IGI IGI: Inferred from genetic interaction	8910344	MGI
contributes to acetylcholine receptor activity	IDA IDA: Inferred from direct assay	8872460	MGI
contributes to acetylcholine-gated monoatomic cation-selective channel activity	IGI IGI: Inferred from genetic interaction	2383398	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21187406	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	2383398	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IPI IPI: Inferred from physical interaction	8910344	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21187406	MGI
located in membrane	IDA IDA: Inferred from direct assay	20053883	MGI
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	4781450	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	16203963	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12388596	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	4781450	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

acetylcholine receptor subunit alpha

Recombinant Chrna1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72141	CHRNA1 Protein, Mouse (His)	P04756 (S21-L230)	≥95%
HY-P72142	CHRNA1 Protein, Mouse (His-SUMO)	P04756 (S21-L230)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02665	CHRNA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna1	NCBI	NCBI:1134

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