2. Gene
  3. Becn1 - beclin 1 Gene

Becn1 - beclin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Beclin1

Gene ID: 114558 | Gene type: protein coding

About Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products(4)

mRNA Protein Name
NM_053739.2 NP_446191.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_001034117.1 NP_001029289.1 beclin-1
NM_053739.2 NP_446191.1 beclin-1

Becn1 Protein Structure

BH3

BH3: pfam15285 (104 - 126)

APG6_N

APG6_N: pfam17675 (132 - 258)

APG6

APG6: pfam04111 (264 - 442)

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  • 448 a.a.
Protein Preferred Names Protein Names

beclin-1

beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)

beclin 1, autophagy related

coiled-coil myosin-like BCL2-interacting protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137506 XST-14 99.26% Unkown
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.51% Unkown
HY-RS01463 BECN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01464 Becn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01465 Becn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Becn1 NCBI NCBI:8678