Becn1 - beclin 1 Gene

Rattus norvegicus

Also known as Beclin1

Gene ID: 114558 | Gene type: protein coding

About Becn1

Primary_assembly 10: 86,231,388-86,246,742 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 63 phenotypes. Biased expression in Kidney (RPKM 276.8), Thymus (RPKM 266.7) and 9 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to metal ion; regulation of apoptotic process; and regulation of vacuole organization. Located in cytoplasm; dendrite; and nucleus. Colocalizes with trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products(4)

mRNA	Protein	Name
NM_053739.2	NP_446191.1	beclin-1
NM_001034117.1	NP_001029289.1	beclin-1
NM_001034117.1	NP_001029289.1	beclin-1
NM_053739.2	NP_446191.1	beclin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25117440	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24879156	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	27769861	RGD
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	16420522	RGD
involved in autophagy	IMP IMP: Inferred from mutant phenotype	16697404	RGD
involved in cellular response to aluminum ion	IEP IEP: Inferred from expression pattern	22138567	RGD
involved in cellular response to amino acid starvation	IEP IEP: Inferred from expression pattern	22835012	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	22540380	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	20539009	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	23314838	RGD
involved in cellular response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	27769861	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20075199	RGD
involved in negative regulation of lysosome organization	IMP IMP: Inferred from mutant phenotype	25561470	RGD
involved in p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	27769861	RGD
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	25561470	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	21490676	RGD
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	RGD
involved in positive regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	30404558	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22449108	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	23187302	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	22927075	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17665967	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	19138675	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	22521819	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	21490676	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11306555	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Becn1 Protein Structure

BH3

APG6_N

APG6

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

beclin-1

beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)	beclin 1, autophagy related
coiled-coil myosin-like BCL2-interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-149954	SARS-CoV-2-IN-39	Inhibitor	99.51%	Unkown
HY-167843	Alborixin	Inhibitor	/	Unkown
HY-RS01463	BECN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01464	Becn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01465	Becn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Becn1	NCBI	NCBI:8678

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