2. Gene
  3. BECN1 - beclin 1 Gene

BECN1 - beclin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATG6; VPS30; beclin1

Gene ID: 8678 | Gene type: protein coding

About BECN1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,810,132-42,824,282 (from NCBI)

This gene has 22 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 32.3), duodenum (RPKM 27.0) and 25 other tissues.

Summary

This gene encodes a protein that regulates Autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

BECN1 Products(8)

mRNA Protein Name
NM_001313998.2 NP_001300927.1 beclin-1 isoform a
NM_001314000.2 NP_001300929.1 beclin-1 isoform c
NM_003766.5 NP_003757.1 beclin-1 isoform a
XM_005257759.4 XP_005257816.1 beclin-1 isoform X1
XM_017025263.3 XP_016880752.1 beclin-1 isoform X1
XM_005257760.5 XP_005257817.1 beclin-1 isoform X2
NM_001313999.1 NP_001300928.1 beclin-1 isoform b
XM_017025264.3 XP_016880753.1 beclin-1 isoform X2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
25891078 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
34796041 GOA
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
23878393 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16417406 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
27853422 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
25891078 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25127057 GOA
Biological Process GO Annotation Evidence Reference Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
25891078 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
10625637 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
23629966 GOA
acts upstream of or within autophagy IMP
IMP: Inferred from mutant phenotype
28747345 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
23184933 GOA
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
34796041 GOA
involved in early endosome to late endosome transport IDA
IDA: Inferred from direct assay
14617358 GOA
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
26783301 GOA
involved in mitophagy IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
23478334 GOA
acts upstream of or within negative regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
19273585 GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process IDA
IDA: Inferred from direct assay
8999962 GOA
involved in positive regulation of attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
23478334 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
21358617 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
27031958 GOA
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
25891078 GOA
involved in receptor catabolic process IMP
IMP: Inferred from mutant phenotype
20643123 GOA
involved in regulation of autophagy IDA
IDA: Inferred from direct assay
16799551 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
20208530 GOA
involved in regulation of macroautophagy IDA
IDA: Inferred from direct assay
10625637 GOA
involved in response to mitochondrial depolarisation IMP
IMP: Inferred from mutant phenotype
23878393 GOA
involved in suppression by virus of host autophagy IDA
IDA: Inferred from direct assay
18797192 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22498477 GOA
located in cytoplasmic side of mitochondrial outer membrane IDA
IDA: Inferred from direct assay
23878393 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23878393 GOA
located in endosome IDA
IDA: Inferred from direct assay
23878393 GOA
colocalizes with mitochondrion IMP
IMP: Inferred from mutant phenotype
23878393 GOA
part of phosphatidylinositol 3-kinase complex, class III IPI
IPI: Inferred from physical interaction
25490155 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BECN1 Protein Structure

BH3

BH3: Beclin-1 BH3 domain, Bcl-2-interacting (105 - 129)

APG6

APG6: Autophagy protein Apg6 (135 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

beclin-1

ATG6 autophagy related 6 homolog

beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)

beclin 1, autophagy related

beclin1-beta

beclin1-gamma

coiled-coil myosin-like BCL2-interacting protein

testis secretory sperm-binding protein Li 215e

BECN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BECN1 Q14457 ZWINT Homo sapiens O95229
IF
23478334
Intra
BECN1 Q14457 ZWINT Homo sapiens O95229
Anti Bait CoIP
23478334
Intra
BECN1 Q14457 ZWINT Homo sapiens O95229
Anti Tag CoIP
20562859
Intra
BECN1 Q14457 MCL1 Homo sapiens Q07820
Anti Bait CoIP
21139567
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
20562859
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
19050071
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
26496610
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
GMS
24056303
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
24034250
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
23316280
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
26783301
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
24472739
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
25594178
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
EM
25490155
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
23364696
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
23954414
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Bait CoIP
23316280
Intra
BECN1 Q14457 PIK3C3 Homo sapiens Q8NEB9
Anti Tag CoIP
24034250
Intra
BECN1 Q14457 AMBRA1 Homo sapiens Q9C0C7
Anti Tag CoIP
20562859
Intra
BECN1 Q14457 AMBRA1 Homo sapiens Q9C0C7
Anti Bait CoIP
23974797
Intra
BECN1 Q14457 AMBRA1 Homo sapiens Q9C0C7
Anti Tag CoIP
23954414
Cross
BECN1 Q14457 P0C6X5-PRO_0000283876 Human coronavirus NL63 P0C6X5-PRO_0000283876
Anti Tag CoIP
25311841
Intra
BECN1 Q14457 VMP1 Homo sapiens Q96GC9
Anti Bait CoIP
23316280
Intra
BECN1 Q14457 BCL2L1 Homo sapiens Q07817-1
Y2H
17446862
Intra
BECN1 Q14457 BCL2L1 Homo sapiens Q07817-1
Anti Tag CoIP
17446862
Intra
BECN1 Q14457 BCL2L1 Homo sapiens Q07817-1
FPS
17446862
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
EM
25490155
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Tag CoIP
26496610
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Validated Y2H
32296183
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
GMS
24056303
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Tag CoIP
35271311
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Bait CoIP
24034250
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Pull Down
19050071
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Tag CoIP
23954414
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Tag CoIP
19050071
Intra
BECN1 Q14457 UVRAG Homo sapiens Q9P2Y5
Anti Tag CoIP
20562859
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Bait CoIP
24034250
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Bait CoIP
25594178
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Tag CoIP
24034250
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Tag CoIP
23954414
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Tag CoIP
20562859
Intra
BECN1 Q14457 RUBCN Homo sapiens Q92622
Anti Tag CoIP
22493499
Intra
BECN1 Q14457 EGFR Homo sapiens P00533
Anti Bait CoIP
24034250
Intra
BECN1 Q14457 EGFR Homo sapiens P00533
Anti Tag CoIP
24034250
Intra
BECN1 Q14457 EGFR Homo sapiens P00533
IF
24034250
Intra
BECN1 Q14457 KRT18 Homo sapiens P05783
Anti Bait CoIP
23112296
Intra
BECN1 Q14457 KRT18 Homo sapiens P05783
Anti Tag CoIP
23112296
Intra
BECN1 Q14457 RAB39A Homo sapiens Q14964
Anti Bait CoIP
24349490
Intra
BECN1 Q14457 VIM Homo sapiens P08670
Anti Tag CoIP
23112296
Intra
BECN1 Q14457 DAPK1 Homo sapiens P53355
Pull Down
19180116
Intra
BECN1 Q14457 DAPK1 Homo sapiens P53355
Anti Tag CoIP
19180116
Intra
BECN1 Q14457 TAB2 Homo sapiens Q9NYJ8
Y2H
22081109
Intra
BECN1 Q14457 TAB2 Homo sapiens Q9NYJ8
Pull Down
22081109
Intra
BECN1 Q14457 TAB2 Homo sapiens Q9NYJ8
Anti Tag CoIP
22081109
Intra
BECN1 Q14457 TAB2 Homo sapiens Q9NYJ8
Anti Bait CoIP
22081109
Intra
BECN1 Q14457 TAB3 Homo sapiens Q8N5C8
Pull Down
22081109
Intra
BECN1 Q14457 TAB3 Homo sapiens Q8N5C8
Anti Tag CoIP
22081109
Intra
BECN1 Q14457 TAB3 Homo sapiens Q8N5C8
Anti Bait CoIP
22081109
Intra
BECN1 Q14457 TAB3 Homo sapiens Q8N5C8
Y2H
22081109
Intra
BECN1 Q14457 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra
BECN1 Q14457 GRB2 Homo sapiens P62993
Anti Bait CoIP
38182563
Intra
BECN1 Q14457 GRB2 Homo sapiens P62993
Anti Tag CoIP
38182563
Intra
BECN1 Q14457 HTT Homo sapiens P42858
Anti Bait CoIP
28445460
Intra
BECN1 Q14457 HTT Homo sapiens P42858
BioID
34524948
Intra
BECN1 Q14457 WASHC1 Homo sapiens A8K0Z3
IF
23974797
Intra
BECN1 Q14457 WASHC1 Homo sapiens A8K0Z3
Anti Bait CoIP
23974797
Intra
BECN1 Q14457 EXOC8 Homo sapiens Q8IYI6
IF
21241894
Intra
BECN1 Q14457 SGF29 Homo sapiens Q96ES7
Validated Y2H
32296183
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Bait CoIP
24034250
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Bait CoIP
23541952
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Bait CoIP
24472739
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Pull Down
19180116
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Tag CoIP
23954414
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Tag CoIP
21358617
Intra
BECN1 Q14457 BCL2 Homo sapiens P10415
Anti Tag CoIP
19050071
Intra
BECN1 Q14457 BCL2L1 Homo sapiens Q07817
Anti Tag CoIP
19180116
Cross
BECN1 Q14457 Slamf1 Mus musculus Q9QUM4
Anti Bait CoIP
22493499
Intra
BECN1 Q14457 ATXN3 Homo sapiens P54252-1
Anti Bait CoIP
28445460
Cross
BECN1 Q14457 Vmp1 Rattus norvegicus Q91ZQ0
Anti Tag CoIP
23316280
Cross
BECN1 Q14457 Vmp1 Rattus norvegicus Q91ZQ0
IF
23316280
Cross
BECN1 Q14457 nef Human immunodeficiency virus P03407
Anti Tag CoIP
23364696
Cross
BECN1 Q14457 vBCL2 Murid herpesvirus 4 P89884
Y2H Array
22028648
Cross
BECN1 Q14457 vBCL2 Murid herpesvirus 4 P89884
ITC
24443581
Cross
BECN1 Q14457 vBCL2 Murid herpesvirus 4 P89884
Anti Tag CoIP
24034250
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Myopathy, X-Linked, With Excessive Autophagy

X-Linked Myopathy With Excessive Autophagy

Xmea

MEAX

Vacuolar Myopathy
Glottis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Glottis

Squamous Cell Carcinoma Of Glottis
Danon Disease

Pseudoglycogenosis Ii

Antopol Disease

Glycogen Storage Disease Iib

Glycogen Storage Disease Type 2b

Glycogen Storage Disease Type Iib

Gsd2b

Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency

Vacuolar Cardiomyopathy And Myopathy X-Linked

Vacuolar Cardiomyopathy And Myopathy, X-Linked

Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly

Gsd2b, Formerly

Gsd Iib, Formerly

Glycogen Storage Cardiomyopathy

Glycogen Storage Disease Limited To The Heart

Pseudoglycogenosis 2

X-Linked Vacuolar Cardiomyopathy And Myopathy

Lysosomal Glycogen Storage Disease With Normal Acid Maltase

Glycogen Storage Disease Due To Lamp-2 Deficiency

Gsd Due To Lamp-2 Deficiency

Glycogenosis Due To Lamp-2 Deficiency

Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity

DAND

Gsd-Iib
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Wolfram Syndrome 2

WFS2
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Macular Degeneration, Age-Related, 14

Age Related Macular Degeneration 14

ARMD14

Macular Degeneration, Age-Related, 14, Reduced Risk Of

Macular Degeneration, Age-Related, Type 14
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Sphingolipidosis

Sphingolipidoses
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport
Leukodystrophy, Hypomyelinating, 12

Hypomyelinating Leukodystrophy 12

HLD12

Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy

Vps11-Related Autosomal Recessive Hypomyelinating Leukoencephalopathy
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Mouth Disease

Mouth Diseases

Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137506 XST-14 99.26% Unkown
HY-149954 SARS-CoV-2-IN-39 Inhibitor 99.51% Unkown
HY-167843 Alborixin Inhibitor / Unkown
HY-RS01463 BECN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01464 Becn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01465 Becn1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BECN1 VGNC VGNC:70044
Mus musculus BECN1 MGD MGI:1891828
Rattus norvegicus BECN1 RGD RGD:620190
Bos taurus BECN1 VGNC VGNC:26463
Felis catus BECN1 VGNC VGNC:60099