Acvr2a - activin receptor IIA Gene

Mus musculus

Also known as Acvr2; ActrIIa; TactrII

Gene ID: 11480 | Gene type: protein coding

About Acvr2a

Chromosome 2: 48,704,121-48,793,281 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 45 phenotypes. Broad expression in CNS E18 (RPKM 16.6), whole brain E14.5 (RPKM 12.4) and 25 other tissues.

Summary

Enables several functions, including BMP Receptor activity; PDZ domain binding activity; and activin binding activity. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and embryonic skeletal system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products(1)

mRNA	Protein	Name
NM_007396.4	NP_031422.3	activin receptor type-2A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP receptor activity	IMP IMP: Inferred from mutant phenotype	26774823	MGI
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	16648306	MGI
enables activin binding	IPI IPI: Inferred from physical interaction	1646080	MGI
enables activin receptor activity	IDA IDA: Inferred from direct assay	8395525	MGI
enables growth factor binding	IMP IMP: Inferred from mutant phenotype	12414726	MGI
enables growth factor binding	IPI IPI: Inferred from physical interaction	11459935	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	8612709	MGI
enables inhibin binding	IPI IPI: Inferred from physical interaction	7890768	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16648306	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17472960	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	26774823	MGI
acts upstream of or within Sertoli cell proliferation	IMP IMP: Inferred from mutant phenotype	11416011	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10452853	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: Inferred from genetic interaction	16991118	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	7885474	MGI
acts upstream of or within gastrulation with mouth forming second	IGI IGI: Inferred from genetic interaction	10452853	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	7885474	MGI
acts upstream of or within mesoderm development	IGI IGI: Inferred from genetic interaction	10452853	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	16330774	MGI
acts upstream of or within penile erection	IMP IMP: Inferred from mutant phenotype	16093358	MGI
acts upstream of or within regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16093358	MGI
acts upstream of or within regulation of signal transduction	IDA IDA: Inferred from direct assay	17936261	MGI
acts upstream of or within sperm ejaculation	IMP IMP: Inferred from mutant phenotype	16093358	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	11459797	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16648306	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	8395525	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr2a Protein Structure

Activin_recp

STKc_ACVR2a

0
100
200
300
400
513 a.a.

Protein Preferred Names

Protein Names

activin receptor type-2A

ACTR-IIA

activin receptor type IIA

Recombinant Acvr2a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75562	ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc)	P27038 (M1-P134)	≥95%
HY-P75563	ACVR2A/Activin RIIA Protein, Mouse (HEK293, His)	P27038 (A20-P134)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99590	Sotatercept		99.61%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99355	Bimagrumab	Inhibitor	99.07%	Phase 3

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acvr2a	NCBI	NCBI:92
Rattus norvegicus	Acvr2a	NCBI	NCBI:29263

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