Acvr2a - activin A receptor type 2A Gene

Rattus norvegicus

Also known as Acvr2; rActR-II

Gene ID: 29263 | Gene type: protein coding

About Acvr2a

Primary_assembly 3: 33,205,523-33,289,968 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues.

Summary

Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development; positive regulation of follicle-stimulating hormone secretion; and response to organic substance. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a Products(1)

mRNA	Protein	Name
NM_031571.3	NP_113759.2	activin receptor type-2A precursor

Acvr2a Protein Structure

Activin_recp

STKc_ACVR2a

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

activin receptor type-2A

ACTR-IIA	activin A receptor, type IIA
activin receptor IIA	activin receptor type IIA
type II activin receptor

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99590	Sotatercept		99.61%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99355	Bimagrumab	Inhibitor	99.07%	Phase 3

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acvr2a	NCBI	NCBI:92
Mus musculus	Acvr2a	NCBI	NCBI:11480

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