Acvr2b - activin receptor IIB Gene

Mus musculus

Also known as ActRIIB; AI047905; 4930516B21Rik

Gene ID: 11481 | Gene type: protein coding

About Acvr2b

Chromosome 9: 119,231,184-119,264,061 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 259 orthologues, 11 paralogues and is associated with 37 phenotypes. Broad expression in CNS E11.5 (RPKM 12.1), whole brain E14.5 (RPKM 7.8) and 2 other tissues.

Summary

Enables activin binding activity; growth factor binding activity; and protein kinase activity. Involved in blood vessel remodeling; negative regulation of cold-induced thermogenesis; and vasculature development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and Insulin secretion. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; nervous system; and sensory organ. Used to study right atrial isomerism and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (Activin A receptor type 2B). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2b Products(2)

mRNA	Protein	Name
NM_007397.3	NP_031423.1	activin receptor type-2B precursor
NM_001313757.1	NP_001300686.1	activin receptor type-2B isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables activin binding	IDA IDA: Inferred from direct assay	15304227	MGI
enables activin binding	IPI IPI: Inferred from physical interaction	1310075	MGI
enables growth factor binding	IMP IMP: Inferred from mutant phenotype	12414726	MGI
enables growth factor binding	IPI IPI: Inferred from physical interaction	11459935	MGI
enables kinase activator activity	IDA IDA: Inferred from direct assay	16806156	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11882656	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	1326537	MGI
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	1326537	MGI
NOT enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	1326537	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10452853	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9242489	MGI
involved in artery development	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	19903896	MGI
acts upstream of or within determination of left/right symmetry	IGI IGI: Inferred from genetic interaction	16991118	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	9242489	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	10921901	MGI
acts upstream of or within gastrulation with mouth forming second	IGI IGI: Inferred from genetic interaction	10452853	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9242489	MGI
acts upstream of or within insulin secretion	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	16845371	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	16845371	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	17849440	MGI
involved in lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	19903896	MGI
involved in lymphatic endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	19903896	MGI
acts upstream of or within mesoderm development	IGI IGI: Inferred from genetic interaction	10452853	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	22586266	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	16330774	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	11714685	MGI
acts upstream of or within organ growth	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within pancreas development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	17849440	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17849440	MGI
acts upstream of or within regulation of signal transduction	IDA IDA: Inferred from direct assay	17936261	MGI
acts upstream of or within response to glucose	IGI IGI: Inferred from genetic interaction	17849440	MGI
involved in retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	19903896	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	16845371	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	16845371	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	16845371	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	16845371	MGI
acts upstream of or within skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	16845371	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	16991118	MGI
involved in venous blood vessel development	IMP IMP: Inferred from mutant phenotype	19903896	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvr2b Protein Structure

Activin_recp

STKc_ACVR2b

0
100
200
300
400
512 a.a.

Protein Preferred Names

Protein Names

activin receptor type-2B

activin receptor type IIB

Acvr2b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Acvr2b	P27040	ACVR1B	Homo sapiens	P36896	Anti Tag CoIP	14966532

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Acvr2b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75535	ACVR2B Protein, Mouse (HEK293, His-hFc)	P27040-1 (S19-T134)	≥95%
HY-P75536	ACVR2B Protein, Mouse (HEK293, His)	P27040 (S19-T134)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99355	Bimagrumab	Inhibitor	99.07%	Phase 3

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acvr2b	NCBI	NCBI:93
Macaca fascicularis	Acvr2b	NCBI	NCBI:102118668
Rattus norvegicus	Acvr2b	NCBI	NCBI:25366

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