SORCS1 - sortilin related VPS10 domain containing receptor 1 Gene

Homo sapiens

Also known as hSorCS

Gene ID: 114815 | Gene type: protein coding

About SORCS1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:106,573,663-107,181,138 (from NCBI)

This gene has 10 transcripts (splice variants), 425 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 5.3), brain (RPKM 3.7) and 16 other tissues.

Summary

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing Receptor Proteins. The VPS10 domain name comes from the yeast Carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

SORCS1 Products(7)

mRNA	Protein	Name
NM_001013031.3	NP_001013049.1	VPS10 domain-containing receptor SorCS1 isoform b precursor
NM_001206569.2	NP_001193498.1	VPS10 domain-containing receptor SorCS1 isoform c precursor
NM_001206570.2	NP_001193499.1	VPS10 domain-containing receptor SorCS1 isoform d precursor
NM_001206571.2	NP_001193500.1	VPS10 domain-containing receptor SorCS1 isoform e precursor
NM_001206572.2	NP_001193501.1	VPS10 domain-containing receptor SorCS1 isoform f precursor
NM_001387556.1	NP_001374485.1	VPS10 domain-containing receptor SorCS1 isoform g precursor
NM_052918.5	NP_443150.3	VPS10 domain-containing receptor SorCS1 isoform a precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12482870	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	12482870	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SORCS1 Protein Structure

PKD

0
200
400
600
800
1000
1168 a.a.

Protein Preferred Names

Protein Names

VPS10 domain-containing receptor SorCS1

VPS10 domain receptor protein SORCS 1

Recombinant SORCS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76650	SorCS1 Protein, Human (HEK293, His)	Q8WY21 (S111-S1099)	≥95%

Related Diseases

Diseases

Alias

Alzheimer Disease 6

Ad6	Alzheimer Disease 6, Late-Onset
Alzheimer'S Disease 6	Alzheimer Disease 6, Late Onset

Alacrima, Achalasia, And Mental Retardation Syndrome

AAMR	Alacrima, Achalasia, And Intellectual Disability Syndrome
Alacrima, Achalasia, And Impaired Intellectual Development Syndrome	Intellectual Disability

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13570	SORCS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SORCS1	VGNC	VGNC:77724
Rattus norvegicus	SORCS1	RGD	RGD:1305910
Felis catus	SORCS1	VGNC	VGNC:65571
Canis familiaris	SORCS1	VGNC	VGNC:46659
Mus musculus	SORCS1	MGD	MGI:1929666
Bos taurus	SORCS1	VGNC	VGNC:35130
Others	SORCS1	NCBI

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