C1QTNF6 - C1q and TNF related 6 Gene

Homo sapiens

Also known as CTFP6; CTRP6; ZACRP6

Gene ID: 114904 | Gene type: protein coding

About C1QTNF6

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,180,166-37,199,423 (from NCBI)

This gene has 7 transcripts (splice variants), 177 orthologues and 23 paralogues. Broad expression in endometrium (RPKM 12.1), placenta (RPKM 6.4) and 16 other tissues.

Summary

Predicted to enable identical protein binding activity. Predicted to be located in extracellular space. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF6 Products(3)

mRNA	Protein	Name
NM_001365878.1	NP_001352807.1	complement C1q tumor necrosis factor-related protein 6 isoform 2 precursor
NM_031910.4	NP_114116.3	complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor
NM_182486.2	NP_872292.1	complement C1q tumor necrosis factor-related protein 6 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32041782	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF6 Protein Structure

Collagen

C1q

0
100
200
278 a.a.

Protein Preferred Names

Protein Names

complement C1q tumor necrosis factor-related protein 6

C1q and tumor necrosis factor related protein 6

C1QTNF6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	C1QTNF6	Q9BXI9	C1QTNF1	Homo sapiens	Q9BXJ1-2	Y2H Array	32296183
Intra	C1QTNF6	Q9BXI9	C1QTNF1	Homo sapiens	Q9BXJ1-2	Y2H Prey Pooling	32296183
Intra	C1QTNF6	Q9BXI9	C1QTNF1	Homo sapiens	Q9BXJ1-2	Validated Y2H	32296183
Intra	C1QTNF6	Q9BXI9	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	C1QTNF6	Q9BXI9	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	C1QTNF6	Q9BXI9	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	C1QTNF6	Q9BXI9	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	C1QTNF6	Q9BXI9	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01732	C1QTNF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	C1QTNF6	VGNC	VGNC:84562
Canis familiaris	C1QTNF6	VGNC	VGNC:38584
Felis catus	C1QTNF6	VGNC	VGNC:60224
Mus musculus	C1QTNF6	MGD	MGI:1919959
Rattus norvegicus	C1QTNF6	RGD	RGD:1307057
Bos taurus	C1QTNF6	VGNC	VGNC:26626

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