2. Gene
  3. CKB - creatine kinase B Gene

CKB - creatine kinase B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29

Gene ID: 1152 | Gene type: protein coding

About CKB

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,519,667-103,522,830 (from NCBI)

This gene has 18 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic Enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in Other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

CKB Products(2)

mRNA Protein Name
NM_001362531.2 NP_001349460.1 creatine kinase B-type isoform 2
NM_001823.5 NP_001814.2 creatine kinase B-type isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables creatine kinase activity IDA
IDA: Inferred from direct assay
8186255 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
19725078 GOA
Biological Process GO Annotation Evidence Reference Source
involved in phosphocreatine biosynthetic process IDA
IDA: Inferred from direct assay
8186255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKB Protein Structure

ATP-gua_PtransN

ATP-gua_PtransN: ATP:guanido phosphotransferase, N-terminal domain (21 - 100)

ATP-gua_Ptrans

ATP-gua_Ptrans: ATP:guanido phosphotransferase, C-terminal catalytic domain (121 - 366)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

creatine kinase B-type

brain creatine kinase

CKB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CKB P12277 CKM Homo sapiens P06732
Anti Tag CoIP
35271311
Intra
CKB P12277 CKM Homo sapiens P06732
Anti Tag CoIP
33961781
Intra
CKB P12277 CKM Homo sapiens P06732
Anti Tag CoIP
28514442
Intra
CKB P12277 ASB9 Homo sapiens Q96DX5
Y2H Pooling
16189514
Intra
CKB P12277 ASB9 Homo sapiens Q96DX5
Validated Y2H
32296183
Intra
CKB P12277 ASB9 Homo sapiens Q96DX5
Y2H Prey Pooling
25416956
Intra
CKB P12277 ASB9 Homo sapiens Q96DX5
Validated Y2H
25416956
Cross
CKB P12277 Q03463-PRO_0000278738 Hepatitis C virus Q03463-PRO_0000278738
Anti Tag CoIP
19264780
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CKB Proteins

Cat. No. Product Name Accession Purity
HY-P7897 Creatine kinase B-type/CKB Protein, Human (His) P12277 (M1-K381) ≥95%

Related Diseases

Diseases Alias
Subendocardial Myocardial Infarction
Neonatal Hypoxic And Ischemic Brain Injury

Perinatal Asphyxia

Hypoxic-Ischemic Encephalopathy

Perinatal Hypoxia

Hie

Hypoxic And Ischemic Brain Injury In The Newborn

Encephalopathy, Hypoxic Ischemic

Encephalopathies Hypoxic-Ischemic

Hypoxic Ischemic Encephalopathy

Hypoxic Ischaemic Brain Injury

Brain Hypoxia

Cerebral Hypoxia

Hypoxic Encephalopathy

Hypoxic Brain Damage

Hypoxic Brain Injury

Brainstem Hypoxia

Hypoxic Brainstem Damage
Acute Myocardial Infarction

Cardiac Attack

Heart Attack
Cardiac Arrest

Cardiopulmonary Arrest

Circulatory Arrest

Heart Arrest
Bacterial Meningitis

Meningitis, Bacterial

Meningitis Bacterial

Bm - [Bacterial Meningitis]

Leptomeningitis Bacterial

Pachymeningitis Bacterial

Arachnoiditis Bacterial
Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Small Cell Cancer Of The Lung

Small Cell Lung Cancer

Small Cell Lung Carcinoma

Sclc

Small-Cell Cancer Of Lung

Lung Small Cell Carcinoma

Sclc1

Sccl

Cancer, Lung, Small Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell
Mitral Valve Insufficiency

Mitral Regurgitation

Congenital Insufficiency Of Mitral Valve

Congenital Mitral Insufficiency

Congenital Mitral Regurgitation

Mitral Valve Incompetence

Mitral Valve Regurgitation

Mr - [Mitral Regurgitation]

Mi - [Mitral Incompetence]

Mitral Valve Annular Incompetency

Congenital Mitral Valve Incompetence

Congenital Mitral Valve Insufficiency

Congenital Mitral Valve Regurgitation

Congenital Mitral Incompetence
Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02736 CKB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CKB VGNC VGNC:108291
Mus musculus CKB MGD MGI:88407
Bos taurus CKB VGNC VGNC:27384
Rattus norvegicus CKB RGD RGD:2357
Felis catus CKB VGNC VGNC:60913
Macaca fascicularis CKB NCBI NCBI:102121556
Others CKB NCBI