Adk - adenosine kinase Gene

Mus musculus

Also known as Ak; 2310026J05Rik; 5033405D03Rik

Gene ID: 11534 | Gene type: protein coding

About Adk

Chromosome 14: 21,102,642-21,498,637 forward strand.GRCm39:CM001007.3

This gene has 10 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 34 phenotypes. Broad expression in liver adult (RPKM 33.3), liver E18 (RPKM 24.2) and 21 other tissues.

Summary

Enables Adenosine Kinase activity and deoxyadenosine kinase activity. Involved in AMP salvage; GMP salvage; and dAMP salvage. Acts upstream of or within dATP biosynthetic process and purine ribonucleoside salvage. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia due to Adenosine Kinase deficiency. Orthologous to human ADK (Adenosine Kinase). [provided by Alliance of Genome Resources, Apr 2022]

Adk Products(2)

mRNA	Protein	Name
NM_134079.4	NP_598840.1	adenosine kinase isoform 1
NM_001243041.1	NP_001229970.1	adenosine kinase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenosine kinase activity	IDA IDA: Inferred from direct assay	718989	MGI
enables adenosine kinase activity	IMP IMP: Inferred from mutant phenotype	28751580	MGI
enables deoxyadenosine kinase activity	IMP IMP: Inferred from mutant phenotype	2835956	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AMP salvage	IDA IDA: Inferred from direct assay	819300	MGI
involved in GMP salvage	IDA IDA: Inferred from direct assay	718989	MGI
involved in dAMP salvage	IMP IMP: Inferred from mutant phenotype	2835956	MGI
acts upstream of or within dATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	12163459	MGI
acts upstream of or within purine ribonucleoside salvage	IDA IDA: Inferred from direct assay	14736855	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	819300	MGI
located in cytosol	IDA IDA: Inferred from direct assay	6407470	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14736855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adk Protein Structure

ribokinase_pfkB_like

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

adenosine kinase

adenosine 5'-phosphotransferase

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P2952	Myokinase, Microorganism		/	Phase 4

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00383	ADK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00384	Adk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00385	Adk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adk	NCBI	NCBI:132

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