ADK - adenosine kinase Gene

Homo sapiens

Also known as AK

Gene ID: 132 | Gene type: protein coding

About ADK

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:74,151,221-74,709,290 (from NCBI)

This gene has 14 transcripts (splice variants), 275 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 10.9), thyroid (RPKM 8.6) and 25 other tissues.

Summary

This gene an Enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the Enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ADK Products(15)

mRNA	Protein	Name
NM_001369123.1	NP_001356052.1	adenosine kinase isoform e
XM_017015703.3	XP_016871192.1	adenosine kinase isoform X5
XM_017015706.2	XP_016871195.1	adenosine kinase isoform X8
NM_001123.4	NP_001114.2	adenosine kinase isoform a
XM_017015699.2	XP_016871188.1	adenosine kinase isoform X3
NM_001202449.2	NP_001189378.1	adenosine kinase isoform c
NM_001202450.2	NP_001189379.1	adenosine kinase isoform d
XM_017015698.2	XP_016871187.1	adenosine kinase isoform X1
NM_006721.4	NP_006712.2	adenosine kinase isoform b
XM_047424621.1	XP_047280577.1	adenosine kinase isoform X9
XM_017015705.2	XP_016871194.1	adenosine kinase isoform X7
XM_017015704.2	XP_016871193.1	adenosine kinase isoform X6
XM_017015702.2	XP_016871191.1	adenosine kinase isoform X4
XM_047424620.1	XP_047280576.1	adenosine kinase isoform X2
NM_001369124.1	NP_001356053.1	adenosine kinase isoform f

ADK Protein Structure

PfkB

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

adenosine kinase

adenosine 5'-phosphotransferase

testicular tissue protein Li 14

Recombinant ADK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75529	ADK/Adenosine Kinase Protein, Human (sf9, His-GST)	AAH03568 (M1-H345)	≥95%
HY-P75530	ADK/Adenosine Kinase Protein, Human (HEK293)	AAH03568 (M1-H345)	≥95%

Related Diseases

Diseases

Alias

Splenic Tuberculosis

Tuberculosis, Splenic

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency	Glycine N-Methyltransferase Deficiency
Met	S-Adenosylhomocysteine Hydrolase Deficiency
Deficiency Of Methionine Adenosyltransferase	Gnmt Deficiency
Mat Deficiency	Methionine Adenosyltransferase Deficiency
Methioninemia	Deficiency Of Acetyl-Coa Acetyltransferase

Purine-Pyrimidine Metabolic Disorder

Inborn Errors Of Purine-Pyrimidine Metabolism

Disorder Of Purine Or Pyrimidine Metabolism

Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia	Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency
Hypermethioninemia Encephalopathy Due To Adk Deficiency	Mrt8
Mental Retardation, Autosomal Recessive 8, Formerly	Mrt8, Formerly
HMAKD	Mental Retardation, Autosomal Recessive 8

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2952	Myokinase, Microorganism		/	Unkown
HY-RS00383	ADK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00384	Adk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00385	Adk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADK	RGD	RGD:2046
Canis familiaris	ADK	VGNC	VGNC:37659
Mus musculus	ADK	MGD	MGI:87930
Macaca mulatta	ADK	VGNC	VGNC:69698
Felis catus	ADK	VGNC	VGNC:59644
Others	ADK	NCBI

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