Adora2b - adenosine A2b receptor Gene

Mus musculus

Also known as A2b; A2BR; A2BAR; AA2BR; ARA2B

Gene ID: 11541 | Gene type: protein coding

About Adora2b

Chromosome 11: 62,139,810-62,157,279 forward strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 37 phenotypes. Broad expression in duodenum adult (RPKM 18.), bladder adult (RPKM 15.8) and 2 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is active in synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b Products(1)

mRNA	Protein	Name
NM_007413.4	NP_031439.2	adenosine receptor A2b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled adenosine receptor activity	IDA IDA: Inferred from direct assay	8157966	MGI
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	16841096	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled adenosine receptor signaling pathway	IDA IDA: Inferred from direct assay	8157966	MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16841096	MGI
acts upstream of cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	11454903	MGI
acts upstream of or within positive regulation of cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	18559975	MGI
acts upstream of or within positive regulation of chronic inflammatory response to non-antigenic stimulus	IMP IMP: Inferred from mutant phenotype	16841096	MGI
acts upstream of or within positive regulation of guanylate cyclase activity	IMP IMP: Inferred from mutant phenotype	18340377	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18559975	MGI
acts upstream of or within positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	11454903	MGI
acts upstream of or within positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	18559975	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	25704806	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	25704806	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	25704806	MGI
acts upstream of or within relaxation of vascular associated smooth muscle	IMP IMP: Inferred from mutant phenotype	18340377	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	25704806	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	25704806	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	25704806	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	25704806	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25704806	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25704806	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12817016	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25704806	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2b Protein Structure

7tmA_Adenosine_R_A2B

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A2b

A2b, Rs

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00397	ADORA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00398	Adora2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00399	Adora2b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora2b	NCBI	NCBI:136

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