2. Gene
  3. ADORA2B - adenosine A2b receptor Gene

ADORA2B - adenosine A2b receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADORA2

Gene ID: 136 | Gene type: protein coding

About ADORA2B

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,850,362-15,975,746 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues.

Summary

This gene encodes an Adenosine Receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates Adenylate Cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

ADORA2B Products(7)

mRNA Protein Name
XM_011523661.3 XP_011521963.1 adenosine receptor A2b isoform X4
XM_047435374.1 XP_047291330.1 adenosine receptor A2b isoform X2
XM_047435373.1 XP_047291329.1 adenosine receptor A2b isoform X2
XM_011523659.4 XP_011521961.1 adenosine receptor A2b isoform X2
XM_017024197.3 XP_016879686.1 adenosine receptor A2b isoform X1
NM_000676.4 NP_000667.1 adenosine receptor A2b
XM_047435375.1 XP_047291331.1 adenosine receptor A2b isoform X3

ADORA2B Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (24 - 290)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

adenosine receptor A2b

Related Diseases

Diseases Alias
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Inner Ear Disease

Labyrinthine Dysfunction

Diseases Of Inner Ear

Labyrinthine Disease

Abnormality Of The Inner Ear

Labyrinth Diseases

Labyrinthine Disorder

Nonfunctioning Labyrinth

Labyrinthine Loss Of Function

Labyrinthine Syndrome

Labyrinthine Disorder Nos
Priapism

Mentulagra

Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection
Subacute Leukemia
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Myocardial Stunning
Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Adenosine Deaminase Deficiency

Ada Deficiency

Ada-Scid

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Adenosine Deaminase Deficient Severe Combined Immunodeficiency

Scid Due To Ada Deficiency

Severe Combined Immunodeficiency Due To Ada Deficiency

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency

Ada

Scid Due To Adenosine Deaminase Deficiency
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADORA2B VGNC VGNC:25688
Mus musculus ADORA2B MGD MGI:99403
Canis familiaris ADORA2B VGNC VGNC:37667
Rattus norvegicus ADORA2B RGD RGD:2050