ADORA2B - adenosine A2b receptor Gene

Homo sapiens

Also known as ADORA2

Gene ID: 136 | Gene type: protein coding

About ADORA2B

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,850,362-15,975,746 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues.

Summary

This gene encodes an Adenosine Receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates Adenylate Cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

ADORA2B Products(7)

mRNA	Protein	Name
XM_011523661.3	XP_011521963.1	adenosine receptor A2b isoform X4
XM_047435374.1	XP_047291330.1	adenosine receptor A2b isoform X2
XM_047435373.1	XP_047291329.1	adenosine receptor A2b isoform X2
XM_011523659.4	XP_011521961.1	adenosine receptor A2b isoform X2
XM_017024197.3	XP_016879686.1	adenosine receptor A2b isoform X1
NM_000676.4	NP_000667.1	adenosine receptor A2b
XM_047435375.1	XP_047291331.1	adenosine receptor A2b isoform X3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29568380	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADORA2B Protein Structure

7tm_1

0
100
200
300
332 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A2b

ADORA2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADORA2B	P29275	ADORA2A	Homo sapiens	P29274	BRET	29568380

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Inner Ear Disease

Labyrinthine Dysfunction	Diseases Of Inner Ear
Labyrinthine Disease	Abnormality Of The Inner Ear
Labyrinth Diseases	Labyrinthine Disorder
Nonfunctioning Labyrinth	Labyrinthine Loss Of Function
Labyrinthine Syndrome	Labyrinthine Disorder Nos

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Subacute Leukemia

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Myocardial Stunning

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Cholera

Vibrio Cholerae Infection	Cholera - Vibrio Cholerae
Cholera Due To Vibrio Cholerae	Vibrio Cholerae
Cholera Syndrome	Asiatic Cholera
Epidemic Cholera

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Adenosine Deaminase Deficiency

Ada Deficiency	Ada-Scid
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency	Adenosine Deaminase Deficient Severe Combined Immunodeficiency
Scid Due To Ada Deficiency	Severe Combined Immunodeficiency Due To Ada Deficiency
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency	Ada
Scid Due To Adenosine Deaminase Deficiency

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00397	ADORA2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00398	Adora2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00399	Adora2b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ADORA2B	VGNC	VGNC:25688
Mus musculus	ADORA2B	MGD	MGI:99403
Canis familiaris	ADORA2B	VGNC	VGNC:37667
Rattus norvegicus	ADORA2B	RGD	RGD:2050

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