1. Gene
  2. TNFRSF13C - TNF receptor superfamily member 13C Gene

TNFRSF13C - TNF receptor superfamily member 13C Gene

Homo sapiens

Also known as BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

Gene ID: 115650 | Gene type: protein coding

About TNFRSF13C

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,922,032-41,926,806 (from NCBI)

This gene has 1 transcript (splice variant), 91 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in spleen (RPKM 19.7), lymph node (RPKM 17.1) and 5 other tissues.

Summary

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

TNFRSF13C Products(1)

mRNA Protein Name
NM_052945.4 NP_443177.1 tumor necrosis factor receptor superfamily member 13C

TNFRSF13C Protein Structure

BaffR-Tall_bind

BaffR-Tall_bind: BAFF-R, TALL-1 binding (16 - 46)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 13C

B cell-activating factor receptor

Recombinant TNFRSF13C Proteins

Cat. No. Product Name Accession Purity
HY-P7130 BAFFR/TNFRSF13C Protein, Human Q96RJ3-1 (M1-G76) ≥95%
HY-P72764 BAFFR/TNFRSF13C Protein, Human (HEK293, His) Q96RJ3-1 (S7-A71) ≥95%
HY-P78065 BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi) Q96RJ3-1 (S7-A71) ≥95%
HY-P700453 BAFFR/TNFRSF13C Protein, Human (HEK293, hFc-Flag) Q96RJ3-1 (S7-A71) ≥95%

Related Diseases

Diseases Alias
Immunodeficiency, Common Variable, 4

CVID4

Antibody Deficiency Due To Baffr Defect

Common Variable Immunodeficiency 4

Immunodeficiency, Variable, Common, Type 4

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Immunodeficiency, Common Variable, 2

CVID2

Antibody Deficiency Due To Taci Defect

Hypogammaglobulinemia Due To Taci Deficiency

Common Variable Immunodeficiency 2

Immunodeficiency, Variable, Common, Type 2

Primary Agammaglobulinemia

Immunoglobulin Deficiency

Antibody Deficiency Syndrome

Antibody

Antibody Deficiency

Gammaglobulin Deficiency

Antibody Deficiency With Near-Normal Immunoglobulins Or With Hyperimmunoglobulinaemia

Immunoglobulin Deficiency With Near-Normal Immunoglobins

Immunoglobulin Deficiency With Hyperimmunoglobulinaemia

Antibody Immunodeficiency With Hyperimmunoglobulinaemia

Antibody Deficiency With Hyperimmunoglobulinaemia

Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Transient Hypogammaglobulinemia Of Infancy

Immunoglobulin Maturational Delay

Thi - [Transient Hypogammaglobulinaemia Of Infancy]

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Cd40 Ligand Deficiency

X-Linked Hyper Igm Syndrome

Hyperimmunoglobulin M Syndrome

Higm1

Hyper-Igm Syndrome Type 1

X-Linked Hyper-Igm Syndrome

Xhigm

Higmx-1

X-Linked Hyper-Igm Immunodeficiency

Hyper-Igm Syndrome 1

Immunodeficiency With Hyper-Igm, Type 1

Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency

Hyper-Igm Syndrome Due To Cd40l Deficiency

Hyper-Igm Immunodeficiency Syndrome

Hyper-Igm Immunodeficiency Syndrome, Type 1

Transient Hypogammaglobulinemia
Trypanosomiasis
B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency

B Cell Deficiencies

Immunoglobulin Heavy Chain Deletion

Humoral Immune Defect

Selective Igg Deficiency Disease

Igg Deficiency

Immunoglobin G Subclass Deficiency

Selective Deficiency Of Igg

Selective Igg Immunodeficiency

Selective Immunoglobulin G Deficiency

Selective Immunoglobulin G Subclass Deficiency

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Immunodeficiency With Hyper-Igm, Type 4

HIGM4

Hyper-Igm Syndrome Type 4

Immunodeficiency With Hyper-Igm Type 4

Hyper-Igm Syndrome 4

Immunodeficiency With Hyper Igm Type 4

Hyper Igm Syndrome 4

Immunodeficiency, With Hyper Igm, Type 4

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Immunoglobulin Alpha Deficiency

Iga Deficiency

Gamma-A-Globulin Deficiency

Immunoglobulin A Deficiency

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Immunodeficiency With Hyper-Igm, Type 3

HIGM3

Immunodeficiency With Hyper Igm Type 3

Hyper-Igm Syndrome Type 3

Hyper-Igm Syndrome 3

Hyper-Igm Syndrome Due To Cd40 Deficiency

Cd40 Deficiency

Type 3 Hyper-Igm Immunodeficiency

Hyper Igm Syndrome 3

Immunodeficiency With Hyper-Igm 3

Hyper-Igm Immunodeficiency Type 3

Immunodeficiency, With Hyper Igm, Type 3

Hyper-Igm Immunodeficiency Syndrome, Type 3

Immunodeficiency With Hyper-Igm, Type 1

Immunodeficiency, X-Linked, With Hyper-Igm

Hyper Igm Syndrome

HIGM1

Xhim

Hyper-Igm Syndrome

Higm

Hyper-Igm Syndrome 1

Immunodeficiency 3

Imd3

Immunodeficiency With Hyper-Igm

Immunodeficiency With Hyper Igm Type 1

Ihis

X-Linked Hyper Igm Syndrome

Hyper-Igm Immunodeficiency, X-Linked

Hyper Igm Immunodeficiency, X-Linked

Hyper Igm Syndrome 1

X-Linked Immunodeficiency With Hyper-Igm 1

Immunodeficiency, With Hyper Igm

Immunodeficiency, With Hyper Igm, Type 1

Hyper-Igm Immunodeficiency Syndrome, Type 1

Hyperimmunoglobulin M Syndrome

Good Syndrome

Immunodeficiency With Thymoma

Thymoma-Immunodeficiency Syndrome

Thymoma With Hypogammaglobulinemia

Thymoma Immunodeficiency

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia

Lip Disease

Lip Diseases

LIP

Disease Of Lips

Autoimmune Disease Of Exocrine System
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris TNFRSF13C VGNC VGNC:54377
Felis catus TNFRSF13C VGNC VGNC:66405
Bos taurus TNFRSF13C VGNC VGNC:57365
Macaca mulatta TNFRSF13C VGNC VGNC:108067
Mus musculus TNFRSF13C MGD MGI:1919299
Rattus norvegicus TNFRSF13C RGD RGD:1560810
Macaca fascicularis TNFRSF13C NCBI NCBI:102116472
Others TNFRSF13C NCBI