Gla - galactosidase, alpha Gene

Mus musculus

Also known as Ags

Gene ID: 11605 | Gene type: protein coding

About Gla

Summary

Enables alpha-galactosidase activity. Involved in negative regulation of nitric oxide biosynthetic process and negative regulation of nitric-oxide synthase activity. Acts upstream of or within glycosylceramide catabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and liver and biliary system. Used to study Fabry disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gla Products(1)

mRNA	Protein	Name
NM_013463.3	NP_038491.2	alpha-galactosidase A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-galactosidase activity	IDA IDA: Inferred from direct assay	198184	MGI
enables alpha-galactosidase activity	IMP IMP: Inferred from mutant phenotype	9122231	MGI
enables hydrolase activity	IDA IDA: Inferred from direct assay	19710420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	32428018	MGI
NOT acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	16697974	MGI
acts upstream of or within glycosylceramide catabolic process	IDA IDA: Inferred from direct assay	10840053	MGI
acts upstream of or within glycosylceramide catabolic process	IMP IMP: Inferred from mutant phenotype	9122231	MGI
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15668341	MGI
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	15668341	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19710420	MGI
located in lysosome	IDA IDA: Inferred from direct assay	15629890	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-galactosidase A

alpha-D-galactosidase A	alpha-D-galactoside galactohydrolase
galactosylgalactosylglucosylceramidase GLA	melibiase

Recombinant Gla Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73077	GLA/alpha-Galactosidase A Protein, Mouse (HEK293, His)	Q8BGZ6 (L34-R421)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2172	Vitamin K		98.70%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112499	Menaquinone-7		≥98.0%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118135	4-Methylumbelliferyl-α-D-galactopyranoside		99.76%	Unkown
HY-W009276	γ-Linolenic Acid methyl ester	Inducer	99.37%	Unkown
HY-112499S1	Menaquinone-7-13C6		≥96.0%	Unkown
HY-112499S	Menaquinone-7-d7		/	Unkown
HY-144003	BAY-R 1005		/	Unkown
HY-RS05463	GLA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gla	NCBI	NCBI:2717
Macaca fascicularis	Gla	NCBI	NCBI:102124721
Rattus norvegicus	Gla	NCBI	NCBI:363494

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