Gla - galactosidase, alpha Gene

Rattus norvegicus

Gene ID: 363494 | Gene type: protein coding

About Gla

Summary

Enables alpha-galactosidase activity and galactoside binding activity. Predicted to be involved in several processes, including glycosylceramide catabolic process; negative regulation of nitric oxide biosynthetic process; and negative regulation of nitric-oxide synthase activity. Located in lysosome. Used to study Fabry disease and lysosomal storage disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gla Products(1)

mRNA	Protein	Name
NM_001108820.3	NP_001102290.2	alpha-galactosidase A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-galactosidase activity	IDA IDA: Inferred from direct assay	8702598	RGD
enables alpha-galactosidase activity	IMP IMP: Inferred from mutant phenotype	8717430	RGD
enables galactoside binding	IDA IDA: Inferred from direct assay	8702598	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycosphingolipid catabolic process	IMP IMP: Inferred from mutant phenotype	34320241	RGD
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	34541380	RGD
involved in platelet activation	IMP IMP: Inferred from mutant phenotype	34320241	RGD
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	34320241	RGD
involved in regulation of axon diameter	IMP IMP: Inferred from mutant phenotype	34541380	RGD
involved in regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	36660199	RGD
involved in sleep	IMP IMP: Inferred from mutant phenotype	36660199	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-galactosidase A

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2172	Vitamin K		98.70%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112499	Menaquinone-7		≥98.0%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118135	4-Methylumbelliferyl-α-D-galactopyranoside		99.76%	Unkown
HY-W009276	γ-Linolenic Acid methyl ester	Inducer	99.37%	Unkown
HY-112499S1	Menaquinone-7-13C6		≥96.0%	Unkown
HY-112499S	Menaquinone-7-d7		/	Unkown
HY-144003	BAY-R 1005		/	Unkown
HY-E70535	Des-Gla-Human Activated Protein C		/	Unkown
HY-E70536	Des-Gla-Human Factor VIIa		/	Unkown
HY-E70537	Des-Gla-Human Factor X		/	Unkown
HY-E70538	Des-Gla-Human Factor XaB		/	Unkown
HY-E70539	Des-Gla-Human Protein C		/	Unkown
HY-E70540	Des-Gla-Human Prothrombin		/	Unkown
HY-RS05463	GLA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gla	NCBI	NCBI:2717
Macaca fascicularis	Gla	NCBI	NCBI:102124721
Mus musculus	Gla	NCBI	NCBI:11605

Name
Email *

	Sorry, but the email address you supplied was invalid.