Agt - angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Gene

Mus musculus

Also known as AngI; AngII; Aogen; Serpina8

Gene ID: 11606 | Gene type: protein coding

About Agt

Summary

Enables type 1 Angiotensin Receptor binding activity and type 2 Angiotensin Receptor binding activity. Involved in positive regulation of cytokine production. Acts upstream of or within several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt Products(1)

mRNA	Protein	Name
NM_007428.4	NP_031454.4	angiotensinogen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables type 1 angiotensin receptor binding	IDA IDA: Inferred from direct assay	9878677	MGI
enables type 2 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	9878677	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9196031	MGI
acts upstream of or within aldosterone secretion	IMP IMP: Inferred from mutant phenotype	9557921	MGI
involved in aldosterone secretion	IMP IMP: Inferred from mutant phenotype	22550170	MGI
acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	10425188	MGI
acts upstream of or within astrocyte activation	IMP IMP: Inferred from mutant phenotype	9734405	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within brain renin-angiotensin system	IDA IDA: Inferred from direct assay	9878677	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	12657564	MGI
NOT acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9734405	MGI
acts upstream of or within drinking behavior	IMP IMP: Inferred from mutant phenotype	9852267	MGI
acts upstream of or within establishment of blood-nerve barrier	IMP IMP: Inferred from mutant phenotype	9734405	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	9734405	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	12660889	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11606482	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9310306	MGI
acts upstream of or within negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9310306	MGI
acts upstream of organ growth	IDA IDA: Inferred from direct assay	16374517	MGI
acts upstream of or within ovarian follicle rupture	IMP IMP: Inferred from mutant phenotype	11384650	MGI
acts upstream of or within peristalsis	IMP IMP: Inferred from mutant phenotype	9788961	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	9196031	MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19404405	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	19023134	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	34615811	MGI
acts upstream of or within positive regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	11606482	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19404405	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	12660889	MGI
acts upstream of or within positive regulation of organ growth	IDA IDA: Inferred from direct assay	16374517	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	12660889	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	23775122	MGI
acts upstream of or within positive regulation of protein kinase C activity	IDA IDA: Inferred from direct assay	23775122	MGI
acts upstream of or within regulation of apoptotic process	IDA IDA: Inferred from direct assay	19404405	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	9557921	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	16585392	MGI
acts upstream of or within regulation of inflammatory response	IDA IDA: Inferred from direct assay	19404405	MGI
acts upstream of or within regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	19404405	MGI
acts upstream of or within regulation of renal output by angiotensin	IMP IMP: Inferred from mutant phenotype	9507198	MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IMP IMP: Inferred from mutant phenotype	7989296	MGI
acts upstream of or within renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	11606482	MGI
acts upstream of or within renin-angiotensin regulation of aldosterone production	IMP IMP: Inferred from mutant phenotype	9852267	MGI
acts upstream of or within response to cold	IMP IMP: Inferred from mutant phenotype	12574102	MGI
acts upstream of or within response to salt stress	IMP IMP: Inferred from mutant phenotype	9557921	MGI
acts upstream of or within smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	9788961	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	9788961	MGI
acts upstream of or within smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	9788961	MGI
acts upstream of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	9788961	MGI
acts upstream of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	8675666	MGI
acts upstream of or within vasopressin secretion	IMP IMP: Inferred from mutant phenotype	9557921	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7989296	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiotensinogen

angiotensin I	angiotensin ll
serpin A8

Recombinant Agt Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73652	Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His)	P11859 (D25-V477)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108764	Mipomersen sodium	Inhibitor	97.50%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W002585	O6-Benzylguanine		99.84%	Phase 3
HY-143230	Custirsen		/	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99530	Valanafusp alfa		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150736	ODN 20844	Inhibitor	/	Unkown
HY-148413	Aprinocarsen sodium	Inhibitor	90.35%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-150215	ODN 105870	Inhibitor	/	Unkown
HY-150216	ODN 105871	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-P5939	Angiotensinogen (1-13) (human)		/	Unkown
HY-RS00466	AGT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agt	NCBI	NCBI:183
Rattus norvegicus	Agt	NCBI	NCBI:24179

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