Agt - angiotensinogen Gene

Rattus norvegicus

Also known as Ang; PAT; ANRT; AngII

Gene ID: 24179 | Gene type: protein coding

About Agt

Summary

Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt Products(1)

mRNA	Protein	Name
NM_134432.2	NP_602308.1	angiotensinogen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	8348686	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21367774	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16286564	RGD
involved in angiotensin-mediated drinking behavior	IDA IDA: Inferred from direct assay	21281609	RGD
involved in angiotensin-mediated drinking behavior	IMP IMP: Inferred from mutant phenotype	9622148	RGD
involved in artery smooth muscle contraction	IDA IDA: Inferred from direct assay	21076237	RGD
involved in associative learning	IDA IDA: Inferred from direct assay	15245880	RGD
involved in cell growth involved in cardiac muscle cell development	IDA IDA: Inferred from direct assay	21376054	RGD
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12130563	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	24431199	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21131638	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17977916	RGD
involved in fibroblast proliferation	IDA IDA: Inferred from direct assay	21419085	RGD
involved in intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16380540	RGD
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	21281454	RGD
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	15951342	RGD
involved in negative regulation of tissue remodeling	IDA IDA: Inferred from direct assay	21167013	RGD
involved in operant conditioning	IDA IDA: Inferred from direct assay	15245880	RGD
involved in positive regulation of L-arginine import across plasma membrane	IDA IDA: Inferred from direct assay	7499219	RGD
involved in positive regulation of L-lysine import across plasma membrane	IDA IDA: Inferred from direct assay	7499219	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	11897768	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	24465706	RGD
involved in positive regulation of cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	8348686	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	22561449	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	24036592	RGD
involved in positive regulation of extracellular matrix constituent secretion	IDA IDA: Inferred from direct assay	21419085	RGD
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	8348686	RGD
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	24184594	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	18388195	RGD
involved in positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	17616753	RGD
involved in positive regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	11100981	RGD
involved in positive regulation of superoxide anion generation	IDA IDA: Inferred from direct assay	21376054	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	24595849	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	24595849	RGD
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	21376054	RGD
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	24168260	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	21423294	RGD
involved in regulation of heart rate	IDA IDA: Inferred from direct assay	11897768	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11282364	RGD
involved in regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	22198171	RGD
involved in renin-angiotensin regulation of aldosterone production	IDA IDA: Inferred from direct assay	21318332	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18388195	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	23855625	RGD
involved in response to muscle activity involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	8252633	RGD
involved in smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	21292788	RGD
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	21367774	RGD
involved in uterine smooth muscle contraction	IDA IDA: Inferred from direct assay	21401609	RGD
involved in vasoconstriction	IDA IDA: Inferred from direct assay	20955746	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	21056585	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8252633	RGD
NOT located in mitochondrion	IDA IDA: Inferred from direct assay	23959064	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiotensinogen

angiotensin II	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
serpin A8

Recombinant Agt Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73651	Serpin A8/Angiotensinogen Protein, Rat (HEK293, His)	P01015 (D25-V477)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108764	Mipomersen sodium	Inhibitor	97.50%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W002585	O6-Benzylguanine		99.84%	Phase 3
HY-143230	Custirsen		/	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99530	Valanafusp alfa		98.42%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150738	ODN 2088	Antagonist	90.41%	Unkown
HY-150736	ODN 20844	Inhibitor	/	Unkown
HY-148413	Aprinocarsen sodium	Inhibitor	90.35%	Unkown
HY-150744	ODN 24888	Inhibitor	/	Unkown
HY-150215	ODN 105870	Inhibitor	/	Unkown
HY-150216	ODN 105871	Inhibitor	/	Unkown
HY-150740	ODN 21595	Inhibitor	/	Unkown
HY-P5939	Angiotensinogen (1-13) (human)		/	Unkown
HY-RS00466	AGT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agt	NCBI	NCBI:183
Mus musculus	Agt	NCBI	NCBI:11606

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