TLCD1 - TLC domain containing 1 Gene

Homo sapiens

Gene ID: 116238 | Gene type: protein coding

About TLCD1

This gene has 4 transcripts (splice variants), 196 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 8.5), lymph node (RPKM 6.1) and 25 other tissues.

Summary

Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TLCD1 Products(2)

mRNA	Protein	Name
NM_001160407.2	NP_001153879.1	TLC domain-containing protein 1 isoform 2
NM_138463.4	NP_612472.1	TLC domain-containing protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in membrane assembly	IMP IMP: Inferred from mutant phenotype	30509349	GOA
involved in phospholipid homeostasis	IMP IMP: Inferred from mutant phenotype	30509349	GOA
involved in plasma membrane organization	IMP IMP: Inferred from mutant phenotype	30509349	GOA
involved in regulation of membrane lipid distribution	IMP IMP: Inferred from mutant phenotype	30509349	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	30509349	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLCD1 Protein Structure

TRAM_LAG1_CLN8

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

TLC domain-containing protein 1

calfacilitin

TLCD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TLCD1	Q96CP7	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	TLCD1	Q96CP7	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TLCD1	Q96CP7	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	TLCD1	Q96CP7	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TLCD1	Q96CP7	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	TLCD1	Q96CP7	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TLCD1	Q96CP7	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	CD40	Homo sapiens	P25942	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	CD40	Homo sapiens	P25942	Y2H Array	32296183
Intra	TLCD1	Q96CP7	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TLCD1	Q96CP7	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	TLCD1	Q96CP7	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TLCD1	Q96CP7	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14561	TLCD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TLCD1	VGNC	VGNC:47393
Mus musculus	TLCD1	MGD	MGI:1915572
Felis catus	TLCD1	VGNC	VGNC:66206
Bos taurus	TLCD1	VGNC	VGNC:35887
Macaca mulatta	TLCD1	VGNC	VGNC:104665
Rattus norvegicus	TLCD1	RGD	RGD:1359195

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